BMI对不同分子亚型女性乳腺癌患者预后影响的回顾性研究

doi:10.11904/j.issn.1002-3070.2026.01.006

Abstract

Abstract: Objective Both obesity and molecular subtypes are important factors affecting the prognosis of breast cancer patients.This article aimed to explore the impact of body mass index(BMI)on breast cancer-specific mortality risk in female breast cancer patients with different molecular subtypes. Methods Clinical data of breast cancer patients diagnosed for the first time at Liaoning Provincial Cancer Hospital from 2016 to 2017 were retrospectively collected,including a total of 2,340 cases of primary,invasive female breast cancer patients.Survival outcomes were obtained through follow-up.The primary outcome measure was breast cancer-specific survival(BCSS).Univariate analysis was conducted on age,BMI,menopausal status,histological grade,tumor stage,Ki-67 expression,and molecular subtype.The Cox proportional hazards model was used to analyze the impact of obesity(BMI≥28 kg/m²)on breast cancer-specific mortality risk in breast cancer patients with different molecular subtypes. Results Among 2,340 breast cancer patients,343 were obese,accounting for 14.7%.The proportion of obese patients was higher in luminal A and triple-negative breast cancer(P=0.005).There were 170 breast cancer deaths,accounting for 7.3%.Compared with non-obese patients(BMI<28 kg/m²)women,obese women had a higher risk of breast cancer mortality(HR=1.629,95% CI:1.118-2.375).Compared with luminal A patients,luminal B subtype(HR=1.918,95% CI:1.236-2.975),human epidermal growth factor receptor 2(HER2)overexpression(HR=2.119,95% CI:1.374-3.270),and triple-negative breast cancer(HR=2.114,95% CI:1.338-3.338)patients had a higher risk of breast cancer-specific mortality.After adjusting for confounding factors,obesity increased risk of breast cancer-specific mortality in patients with luminal A patients(HR=2.255,95% CI:1.338-3.802). Conclusion Obesity may be an independent risk factor for prognosis in patients with luminal A breast cancer,whereas no statistically significant association was observed in other molecular subtypes.

Key words: breast cancer, female, body mass index, molecular subtype, prognosis

CLC Number:

ZUO Tingting, YU Zhifu, SHEN Zhan, WANG Chenyu, ZHU Bo. The impact of BMI on the prognosis of female breast cancer patients with different molecular subtype:A retrospective study[J]. Journal of Practical Oncology, 2026, 40(1): 41-47.

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The impact of BMI on the prognosis of female breast cancer patients with different molecular subtype:A retrospective study

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