The Turpan Basin is an intermountain basin in the Tianshan Mountains. A good preservation of the Paleogene in this basin provides abundant information for studying of the Paleogene climate in  Northwest China. Based on various climatic proxies from a section at Lamjin in the Turpan Basin， such as Fe₂O₃， FeO， CaCO₃， organic carbon and organic carbon stable isotopes， this paper focuses on climatic changes and key climatic events during the Paleogene. Temperatures of the Paleogene in the Turpan Basin are estimated by the ratios of Fe₃+/Fe₂+. Annual mean temperatures were 22.35℃ in the Paleocene， 21.82℃ in the Eocene and 15.69℃ in the Oligocene respectively. A key temperaturefalling event took place during the transitional period from the Late Eocene to the Early Oligocene. Researches on CaCO₃ content of the Paleogene indicate that the mean content of CaCO₃ was 4.68％ in the Paleocene and 6.66％ in the Eocene respectively， while the mean content of CaCO₃ reached 15.01％ in the Oligocene. These data show that the climates in the Paleocene and Eocene were relatively humid， while arid in the Oligocene. Values of organic carbon stable isotopes(δ¹³Corg)from the Paleogene sediments concentrate in the scope of the C3 plants， which indicates C3 plants were  developed in the Turpan Basin at that time， and δ¹³Corg values have a negative relationship with CaCO₃ content but a positive relationship  with temperatures. Namely， a decrease of the δ¹³Corg value corresponds to an increase of the CaCO3 content and a fall of the temperature. The various climatic proxies indicate that the climate was relatively warm and humid in the Paleocene and Eocene， while arid and cool in the Oligocene.