实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (5): 456-459.doi: 10.11904/j.issn.1002-3070.2014.05.017

• 综述 • 上一篇    下一篇

Toll样受体4在恶性淋巴瘤中的作用

郭莉1 综述,张清媛2 审校   

  1. 1.哈尔滨医科大学附属肿瘤医院呼吸肿瘤科(哈尔滨 150081);
    2.哈尔滨医科大学附属肿瘤医院乳腺肿瘤科
  • 收稿日期:2014-06-23 出版日期:2014-10-28 发布日期:2014-10-28
  • 通讯作者: 张清媛,E-mail:zhma19650210@163.com
  • 作者简介:郭莉,女,(1979-),博士研究生,主治医师,从事肿瘤内科的研究
  • 基金资助:
    黑龙江省卫生厅课题(2013149)

The role of Toll-like receptor 4 in malignant lymphoma

GUO Li1,ZHANG Qingyuan2   

  1. 1.Department of Respiratory Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
    2.Department of Breast Cancer,The Affiliated Tumor Hospital of Harbin Medical University
  • Received:2014-06-23 Online:2014-10-28 Published:2014-10-28

摘要: 恶性淋巴瘤的发病机制一直是肿瘤研究的一个重要课题,但至今尚不完全明确。最近有临床研究表明TLR4(Toll-like receptor 4,TLR4)在套细胞淋巴瘤组织中和多种淋巴瘤细胞系中均有较高表达,且与预后有一定相关性。本文对TLR4在恶性淋巴瘤发生发展中的作用做一综述,以阐明淋巴瘤发病机制并为其治疗提供新的依据。

Abstract: The pathogenesis of malignant lymphoma has been an important topic in tumor research,but it is still unclear.Recent clinical studies showed that the expression level of Toll-like receptor 4(TLR4)was significantly high in mantle cell lymphoma tissue and a variety of lymphoma cell lines.At the same time,the TLR4 expression level was correlated with prognosis.The Role of TLR4 in malignant lymphoma for occurrence and development is reviewed in this article,which may elucidate the pathogenesis and provide a new basis for the therapy of lymphoma.

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