Abstract: Tumor growth and migration are correlated with continuous neovascularization.Slit2-Robo1 signal pathway initially positioned in the nervous system plays an important role in the growth and neuronal axon guidance during migration.However,vascular system resembles the structural features and growth mechanism of neural system.Recent researches have shown that Slit2-Robo1 signaling pathway plays an important role in vascular system,especially in tumor vessel.And Slit2-Robo1 has been shown to play a role in brain metastasis in breast cancer and supporting tumor growth in melanoma.Therefore,the role of Slit2-Robo1 in tumor growth and migration depends on the cancer type.Currently,researches in this field show controversial results.And the status of Slit2-Robo1 signaling pathway in lung cancer is reviewed in this essay.