肿瘤细胞和亚细胞器治疗靶标的研究

doi:10.11904/j.issn.1002-3070.2014.06.014

实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (6): 549-552.doi: 10.11904/j.issn.1002-3070.2014.06.014

肿瘤细胞和亚细胞器治疗靶标的研究

张百红¹综述, 岳红云²审校

1.兰州军区兰州总医院肿瘤科(兰州 730050);
2.兰州军区兰州总医院眼科

收稿日期:2014-07-23 出版日期:2014-12-28 发布日期:2015-01-08
通讯作者: 张百红,E-mail:bhzhang1999@126.com
作者简介:张百红,男,(1970-),博士,副主任医师,从事消化道肿瘤的基础和临床研究
基金资助:
2013年甘肃省自然科学基金项目(1308RJZA181)

Study of cellular and sub-cellular organelles targets on cancer therapy

ZHANG Baihong¹,YUE Hongyun²

1.Department of Oncology,General Hospital of People′s Liberation Army,Lanzhou 730050,China;
2.Department of Ophthalmology,General Hospital of People′s Liberation Army

Received:2014-07-23 Online:2014-12-28 Published:2015-01-08

摘要/Abstract

摘要：

各种细胞类型和亚细胞器都是肿瘤治疗的靶标,这些靶标包括肿瘤起始细胞、肿瘤干细胞、循环肿瘤细胞、转移起始细胞、骨髓来源细胞和基质细胞等细胞类型,以及线粒体、溶酶体、内质网、胞外膜泡、中心体和核仁等亚细胞器。靶向不同肿瘤细胞群和亚细胞器的治疗增加了肿瘤靶向治疗的内容,也使肿瘤个体化治疗成为可能。

关键词: 肿瘤细胞, 亚细胞器, 治疗靶标

Abstract:

Tumor cell type and sub-cellular organelle are potential targets for cancer therapy.These targets have cell types including tumor-initiating cells,cancer stem cells,circulating tumor cells,metastasis-initiating cells,bone marrow derived cells and stromal cells,as well as sub-cellular organelles including mitochondria,lysosome,endoplasmic reticulum,extracellular vesicles,centrosome and nucleolus.New targets should provide more targeted therapy and personalized therapy for patients with human cancers.

Key words: Cancer cells, Sub-cellular organelles, Therapeutic targets

中图分类号:

R734.2

张百红综述, 岳红云审校. 肿瘤细胞和亚细胞器治疗靶标的研究[J]. 实用肿瘤学杂志, 2014, 28(6): 549-552.

ZHANG Baihong,YUE Hongyun. Study of cellular and sub-cellular organelles targets on cancer therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 549-552.

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肿瘤细胞和亚细胞器治疗靶标的研究

Study of cellular and sub-cellular organelles targets on cancer therapy

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