胃癌与肿瘤微环境的研究进展

doi:10.11904/j.issn.1002-3070.2014.06.017

摘要/Abstract

摘要：

胃癌(Gastric carcinoma,GC)的发病率居全世界恶性肿瘤的第四位,死亡率居第二位。尽管胃癌的发病率在过去的几十年里有所下降,但它仍然是一个严重危害健康的问题。肿瘤微环境在肿瘤的发生和进展中有重要作用,主要包括肿瘤相关的巨噬细胞、淋巴细胞、癌相关成纤维细胞、血管生成因子、细胞因子、肿瘤微环境以及它们作用机制的信号趋化因子等。本文就肿瘤微环境与胃癌相关性的研究进展综述如下。

关键词: 胃癌, 肿瘤微环境, 幽门螺杆菌

Abstract:

Gastric cancer is the fourth malignancies and the second cancer-related mortality rate in the world.Although the incidence of gastric cancer has declined in the past few decades,it is still a serious health problem.Tumor microenvironment plays an important role in tumorigenesis and progression.The main components of gastric cancer include tumor associated macrophages、lymphocytes、cancer-associated fibroblasts、angiogenesis factors,cytokines,gastric microenvironment and the mechanism of action of chemokines.In this review,the correlation between tumor microenvironment and GC is discussed.

Key words: Gastric cancer, Tumor microenvironment, Helicobacter pylori

中图分类号:

R735.2

王涛, 郑永光, 范康武综述, 李玉民审校. 胃癌与肿瘤微环境的研究进展[J]. 实用肿瘤学杂志, 2014, 28(6): 561-564.

WANG Tao,ZHENG Yongguang,FAN Kangwu,LI Yumin. Progress on relationship between gastric cancer and tumor microenvironment[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 561-564.

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