Abstract: EphA7 is one of the most important members of the Eph family.It is a key regulatory factor of cell adhesion and repulsion,it also contributes to establish men,maintain ance and tissue remodeling in cell morphology.In recent years,its function in tumors has been revealed gradually.It plays a variety of roles in different tumors.The overexpression of EphA7 can be detected in acute leukemia,glioblastomamultiforme,lung cancer and hepatic carcinoma,which suggests EphA7 may be involved in the development of these tumors.While in colon cancer,prostate cancer,follicular lymphoma and gastric cancer,a significant reduction of EphA7 expression with promoter hypermethylation is discovered,which suggests EphA7 play a tumor suppressor role in these tumors.Even though the function of EphA7 is still under exploration,EphA7 and tumor development are inextricably linked,it may have roles in the pathogenesis and development of these carcinomas.