AEG-1、MMP-9在结直肠组织中的表达及临床病理相关性的研究

doi:10.11904/j.issn.1002-3070.2015.03.002

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 197-202.doi: 10.11904/j.issn.1002-3070.2015.03.002

AEG-1、MMP-9在结直肠组织中的表达及临床病理相关性的研究

宋鸿涛, 秦誉, 李聪, 姚国栋, 王恕怀, 耿敬姝

哈尔滨医科大学附属肿瘤医院病理科(哈尔滨 150081)

收稿日期:2015-02-05 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 耿敬姝 E-mail:gengjingshu@aliyun.com
作者简介:宋鸿涛,男,(1978-),博士,副主任医师,从事消化道肿瘤侵袭与转移的研究。
基金资助:
黑龙江省教育厅资助项目(12511175)

Study on the association between expression and clinicopathological significance of AEG-1 and MMP-9 in colorectal tissue

SONG Hongtao,QIN Yu,LI Cong,YAO Guodong,WANG Shuhuai,GENG Jingshu

Department of Pathology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-02-05 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

目的探讨星形细胞上调基因1(AEG-1)和基质金属蛋白酶9(MMP-9)在结直肠组织中的表达并分析其与结直肠癌的临床病理因素之间的相关性。方法应用免疫组化技术检测AEG-1和MMP-9在结直肠正常黏膜(45例)、低级别腺瘤(31例)、高级别腺瘤(15例)和结直肠癌(146例)中的表达,并分析其表达的意义。结果 AEG-1在结直肠正常黏膜、低级别腺瘤、高级别腺瘤和结直肠癌中有逐步升高的趋势。MMP-9表达与AEG-1有类似的趋势。AEG-1在结直肠癌组织中的阳性表达率与临床分期、T分期、N分期、M分期及组织分化有统计学差异(P＜0.05),而与年龄、性别、肿瘤位置和肿瘤大小无统计学差异(P＞0.05)。在结直肠癌中,AEG-1和MMP-9表达呈显著正相关,AEG-1、MMP-9高表达的患者具有较短的生存期(P＜0.05)。结论 AEG-1参与结直肠癌的发生,与结直肠癌的演进相关,并可能作为结直肠癌患者预后的一种新的生物标志物。

关键词: 星形细胞上调基因1, 基质金属蛋白酶9, 结直肠癌, 结直肠腺瘤

Abstract:

Objective To investigate the expression of astrocyte elevated gene-1(AEG-1)and matrix metallopeptidase 9(MMP-9)in colorectal tissues and evaluate its correlation with clinical pathologic factors of colorectal cancer.Methods AEG-1 and MMP-9 expression in normal colorectal mucous(n=45),low-grade adenoma(n=31),high-grade adenoma(n=15)and colorectal carcinoma(n=146)were examined by immunohistochemistry.Statistical analyses were applied to test the significance of its expression.Results AEG-1 expression levels were gradually elevated in normal tissues,low-grade adenoma,high-grade adenoma and colorectal carcinoma respectively.Furthermore,there was a similar trend for MMP-9 from normal mucous to adenoma and carcinoma.Statistical analysis revealed that AEG-1 expression was markedly correlated with the UICC stage,T classification,N classification,M classification,and histological differentiation in the colorectal cancer patients,but not with age,gender,tumor location and tumor size.In addition,AEG-1 expression was positively correlated with the MMP-9 expression in colorectal cancer.Besides,those patients with high AEG-1 and MMP-9 levels had shorter survival time(P＜0.05).Conclusion AEG-1 may be involved in carcinogenesis and progression of colorectal carcinoma and can be a novel prognostic biomarker in patients with colorectal carcinoma.

Key words: Astrocyte elevated gene-1, Matrix metalloproteinase-9, Colorectal carcinoma, Colorectal adenoma

中图分类号:

R735.34

宋鸿涛, 秦誉, 李聪, 姚国栋, 王恕怀, 耿敬姝. AEG-1、MMP-9在结直肠组织中的表达及临床病理相关性的研究[J]. 实用肿瘤学杂志, 2015, 29(3): 197-202.

SONG Hongtao,QIN Yu,LI Cong,YAO Guodong,WANG Shuhuai,GENG Jingshu. Study on the association between expression and clinicopathological significance of AEG-1 and MMP-9 in colorectal tissue[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 197-202.

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AEG-1、MMP-9在结直肠组织中的表达及临床病理相关性的研究

Study on the association between expression and clinicopathological significance of AEG-1 and MMP-9 in colorectal tissue

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