靶向血管生成拟态治疗肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2015.04.016

摘要/Abstract

摘要： 肿瘤微血管包括由血管内皮细胞围成的经典血管结构和由肿瘤细胞围成的血管生成拟态(Vasculogenic mimicry,VM)两种模式。近年研究提示,抗血管生成药能够显著抑制经典的微血管结构,但是不能抑制VM形成,反而促进VM形成。这是影响其临床疗效的原因之一。然而近期研究发现,中成药、基因治疗以及其它靶向VM形成机制的药在抗VM形成中具有独特的优势。本文就目前靶向VM形成治疗肿瘤的研究现状展开综述,为开发既能抗血管生成又能抗VM形成的新一代抗血管生成药提供借鉴。

关键词: 血管生成拟态, 肿瘤治疗, 抗血管生成

Abstract: Tumor microvessel including two modes,as one is classic vascular structures surrounded with vascular endothelial cells and the other is vasculogenic mimicry(VM)surrounded with cancer cells.Recent studies suggested that anti-angiogenic drugs can inhibit classic microvessel structure significantly,but can not inhibit VM formation and even promote VM formation further more.This is one of the reasons affecting its clinical efficacy.However,basic research has shown that traditional chinese medicine,gene therapy and drugs which is targeting for VM formation have an unique advantage in anti-VM.In this review,we summarize the progress of cancer therapy on targeting vasculogenic mimicry,and provide a basic for the development of new drugs for cancer therapy through targeting both angiogenesis and VM formation.

Key words: Vasculogenic mimicry, Cancer therapy, Antiangiogenic

中图分类号:

R735.3

李富荣,程先硕,李云峰. 靶向血管生成拟态治疗肿瘤的研究进展[J]. 实用肿瘤学杂志, 2015, 29(4): 359-363.

LI Furong,CHENG Xianshuo,LI Yunfeng. Advances in cancer therapy by targeting vasculogenic mimicry[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 359-363.

参考文献

1 Maniotis AJ,Folberg R,Hess A,et al.Vascular channel formation by human melanoma cells in vivo and in viitro:Vasculogenic mimicry[J].Am J Patho I,1999,155(3):739-752.
2 Li M,Gu Y,Zhang Z,et al.Vasculogenic mimicry:a new prognostic sign of gastric adenocarcinoma[J].Pathol Oncol Res,2010,16(2):259-266.
3 牛多山,葛霞.肿瘤血管生成拟态的研究进展[J].实用肿瘤学杂志,2007,21(3):80-82.
4 Sun T,Zhao N,Zhao XL,et al.Expression and functional significance of Twist1 in hepatocellular carcinoma:its role in vasculogenic mimicry[J].Hepatology,2010,51(2):545-556.
5 Baeten CI,Hillen F,Pauwels P,et al.Prognostic role of vasculogenic mimicry in colorectal cancer[J].Dis Colon Rectum,2009,52(12):2028-2035.
6 Heath VL,Bicknell R.Anticancer strategies involving the vasculature[J].Nat Rev Clin Oncol,2009,6(7):395-404.
7 Pacz-Ribes M,Allen E,Hudock J,et al.Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis[J].Cancer Cell,2009,15(3):220-231.
8 Carbone C,Moccia T,Zhu C,et al.Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype[J].Clin Cancer Res,2011,17(17):5822-5832.
9 Soda Y,Myskiw C,Rommel A,et al.Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme[J].J Mol Med(Berl),2013,91(4):439-448.
10 Xu Y,Li Q,Li XY,et al.Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis[J].J Exp Clin Cancer Res,2012,31(1):16.
11 Vander Schaft DW,Seftor RE,et al.Effects of angiogenesis inhibitors on vascular network seftor EA formation by human endothelial and melanoma cells[J].J Nat I Cancer Inst,2004,96(19):1473-1477.
12 Soda Y,Marumoto T,Fried mann-Morvinski D,et al.Trans differentiation of glioblastoma cells into vascular endothelial cells[J].Proc NatI Acad Sci USA,2011,108(11):4274-4280.
13 Liu ZC,Li Y,Zhao W,et al.Demonstration of vasculogenic mimicry in astrocytomas and effects of Endostar on U251 cells[J].Pathol Res Pract,2011,207(10):645-651.
14 Conley SJ,Gheordunescu E,Kakarala P,et al.Anti angio genic agents increase breast cancer stem cells via the generation of tumor hypoxia[J].Proc NatI Acad Sci USA,2012,109(8):2784-2789.
15 Karroum A,Mirshahi P,Faussat AM.et al.Tubular network formation by adriamycin-resistant MCF-7 breast cancer cells is closely linked to MMP-9 and VEGFR-2/VEGFR-3 over-expressions[J].Eur J Pharmacol,2012,685(1-3):1-7.
16 Yadav VR,Aggarwal BB.Curcumin a component of the golden spice,targets multiple angiogenic pathways[J].Cancer Biol Ther,2011,11(2):236-241.
17 韩冰冰,李洁.天花粉蛋白对小鼠黑色素移植瘤血管生成拟态及PI3K表达的影响[J].中药药理与临床,2013,29(3):38-40.
18 Hu A,Huang JJ,Jin XJ,et al.Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway[J].Am J Cancer Res,2015,5(1):278-288.
19 高丽,徐长亮,奚涛,等.丹参酮ⅡA对乳腺癌细胞株MDA-MB-231体外血管生成拟态的抑制作用[J].药学与临床研究,2011,19(4):315-317.
20 Luan YY,Liu ZM,Zhong JY,et al.Effect of grape seed proanthocyanidins on tumor vasculogenic mimicry in human triple-negative breast cancer cells[J].Asian Pac J Cancer Prev,2015,16(2):531-535.
21 Cong R,Sun Q,Yang L,et al.Effect of genistein on vasculogenic mimicry formation by human uveal melanoma cells[J].J Exp Clin Cancer Res,2009,28(1):124.
22 Liu R,Cao Z,Tu J,et al.Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry[J].Pigment Cell Melanoma Res,2012,25(5):630-638.
23 刘曼曼,余涛,陈昊,等.抑癌方对小鼠结肠癌移植瘤微血管及血管拟态形成的影响[J].安徽中医学院学报,2011,30(1):42-45.
24 虞迪,朱峰妍,曹志飞,等.毛莨有效部分D1对人胃癌细胞MGC803血管生成拟态的作用及其机制[J].中国药理学通报,2013,29(2):261-265.
25 郑安红,张维东,王兆明,等.蝎毒多肽提取物联合5-氟尿嘧啶对H22肝癌血管生成拟态形成的作用及机制研究[J].中国中西医结合杂志,2013,33(4):492-496.
26 高启龙,陈永强,李柏,等.蜂毒素抗骨肉瘤裸鼠移植瘤的作用及对肿瘤血管生成拟态的影响[J].肿瘤,2008,28(9):77l-775.
27 孔祥琳,程先硕,李富荣,等.sTie2通过阻抑血管生成拟态抑制结肠癌HCT116细胞的增殖、迁移和侵袭[J].中国肿瘤生物治疗杂志,2013,20(5):522-528.
28 Millimaggi D,Mari M,D′Ascenzo S,et al.Vasculogenic mimicry of human ovarian cancer cells:role of CD147[J].Int J Oncol,2009,35(6):1423-1428.
29 Liu Z,Li Y,Zhao W,et al.Demonstration of vasculogenic mimicry in astrocytomas and effects of Endostar on U251 cells[J].Pathol Res Pract,2011,207(10):645-651.
30 Chen LX,He YJ,Zhao SZ,et al.Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model[J].Cancer Biol Ther,2011,11(2):229-235.
31 Tang NN,Zhu H,Zhang HJ,et al.HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells[J].World J Gastroenterol,2014,20(47):17894-17904.
32 Le Mercier M,Fortin S,Mathieu V,et al.Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression[J].Neoplasia,2009,11(5):485-496.
33 Su F,Li B,Wang J,et al.Molecular regulation of vasculogenic mimicry in human uveal melanoma cells:role of helix-loop-hehx ld2(inhibitor of DNA binding 2)[J].Grades Arch Clin Exp Ophthalmol,2009,247(3):411-419.
34 Liu W,Xu G,Ma J,et al.Osteopontin as a key mediator for vasculogenic mimicry in hepatocellular carcinoma[J].Tohoku J Exp Med,2011,224(1):29-39.
35 许刚柱,李文,张鹏,等.RNA干扰技术下调CEACAM1基因表达对胶质瘤血管生成的影响[J].实用肿瘤学杂志,2014,28(6):514-518.
36 Plantamura I,Casalini P,Dugnani E,et al.PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells[J].Mol Oncol,2014,8(5):968-981.
37 Zhang S,Fu Z,Wei J,et al.Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer[J].Med Oncol,2015,32(1):414.
38 Su M,Feng YJ,Yao LQ,et al.Plasticity of ovarian cancer cell SKOV3ip and vasculogenic mimicry in vivo[J].Tnt Gynecol Cancer,2008,18(3):476-486.
39 Gao R,Cai C,Gan J,et al.miR-1236 down-regulates alpha-fetoprotein,thus causing PTEN accumulation,which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells[J].Oncotarget,2015,6(8):6014-6028.
40 Hess AR,Postovit LM,Margaryan NV,et al.Focal adhesion kinase promotes the aggressive melanoma phenotype[J].Cancer Res,2005,65(21):9851-9860.
41 Hess AR,Seftor EA,Gruman LM,et al.VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway:implications for vasculogenic mimicry[J].Cancer Biol Ther,2006,5(2):228-233.
42 Seftor EA,Meltzer PS,Kirschmann DA,et al.Molecular determinants of human uveal melanoma invasion and metastasis[J].Clin Exp Metastasis,2002,19(3):233-246.
43 Robertson FM,someone AM,Lucci A,et al.Differential regulation of the aggressive phenotype of inflammatory breast cancer by prostanoid receptors EP3 and EP4[J].Cancer,2010,116(11 suppl):2806-2814.
44 Liu X,Wang X,Du W,et al.Suppressor of fused(Sufu)represses Gli1 transcription and nuclear accumulation,inhibits glioma cell proliferation,invasion and vasculogenic mimicry,improving glioma chemo-sensitivity and prognosis[J].Oncotarget,2014,5(22):11681-11694.
45 Li JW,Ke YQ,Huang M,et al.Inhibitory effects of B-cell lymphoma 2 on the vasculogenic mimicry of hypoxic human glioma cells[J].Exp Ther Med,2015,9(3):977-981.

[1]	丁界先, 张津, 陈永刚, 王兴文综述, 王栓科审校. Wnt信号通路与肿瘤发生的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 73-77.
[2]	梁语丝, 谭永刚, 邹华伟审校. 低剂量化疗作用机制的研究进展[J]. 实用肿瘤学杂志, 2017, 31(6): 538-542.
[3]	代欣综述, 张大昕审校. 非小细胞肺癌抗血管生成治疗研究现状[J]. 实用肿瘤学杂志, 2017, 31(5): 472-476.
[4]	宗卫娇芦凤亮刘晔综述金艾顺审校. 全人源抗TRAIL-R1/-R2单克隆抗体肿瘤治疗的研究进展[J]. 实用肿瘤学杂志, 2014, 28(4): 344-348.
[5]	张,悦,张清媛,赵,红,汤大北,甄丽娜. 肿瘤特异性Th1细胞联合脂质体多肽抗肿瘤活性研究[J]. 实用肿瘤学杂志, 2013, 27(5): 391-395.
[6]	张翼翔, 马长宏综述, 王雯雯审校. 凋亡抑制蛋白Livin的最新研究与应用[J]. 实用肿瘤学杂志, 2009, 23(3): 275-277.
[7]	张依综述, 姜达审校. 间充质干细胞及其在肿瘤治疗中的应用[J]. 实用肿瘤学杂志, 2009, 23(3): 282-286.
[8]	李洪滨;刘玮璐;张清媛;康欣梅;赵文辉. 低剂量环磷酰胺联合人参皂甙Rg3治疗晚期非小细胞肺癌疗效分析[J]. 实用肿瘤学杂志, 2006, 20(01): 18-20.