MRI弥散加权成像对宫颈癌新辅助化疗评估的应用价值

doi:10.11904/j.issn.1002-3070.2015.06.008

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (6): 518-522.doi: 10.11904/j.issn.1002-3070.2015.06.008

MRI弥散加权成像对宫颈癌新辅助化疗评估的应用价值

巴志昌¹, 王欣欣¹, 崔万辉², 国飞¹, 张修石¹

1.哈尔滨医科大学附属肿瘤医院放射诊断科(哈尔滨 150081);
2.哈尔滨骨伤科医院

收稿日期:2015-09-13 出版日期:2015-12-28 发布日期:2015-12-28
通讯作者: 张修石,E-mail:xiushiz@126.com E-mail:xiushiz@126.com
作者简介:巴志昌,男,(1982-),硕士,主治医师,从事消化道肿瘤及骨肿瘤的研究

Value of diffusion weighted magnetic resonance imaging in the monitoring of neoadjuvant chemotherapy efficacy for uterine cervical cancer

BA Zhichang¹, WANG Xinxin¹, CUI Wanhui², GUO Fei¹, ZHANG Xiushi¹

1.Department of Diagnostic Radiology,The Affiliated Hospital of Harbin Medical University,Harbin 150081,China;
2.Harbin Orthopedics Hospital

Received:2015-09-13 Online:2015-12-28 Published:2015-12-28

摘要/Abstract

摘要： 目的探讨磁共振扩散加权成像(DWI)对宫颈癌新辅助化疗疗效的评估价值。方法收集我院经病理证实的31例宫颈癌患者,均于新辅助化疗前后行常规MRI及DWI检查,评估化疗前后肿瘤的DWI图像及其ADC值的变化。结果治疗前肿瘤最大横径(37.10±11.23)与治疗前ADC值(0.83±0.12)之间的相关关系没有统计学意义(r=-0.175,P=0.348);治疗后肿瘤最大横径(24.03±5.65)与治疗后ADC值(1.10±0.16)之间的相关性没有统计学意义(r=-0.208,P=0.262);治疗前后肿瘤横径缩小程度与ADC增加之间相关性具有统计学意义(r=0.419,P=0.019);化疗有效组20例,无效组11例,有效组治疗后ADC值(0.95±0.13)较治疗前ADC值(0.80±0.12)明显升高,其变化具有统计学意义(P＜0.05),而无效组治疗前ADC值(0.88±0.10)与治疗后ADC值(0.95±0.13)差异无统计学意义(P＞0.05)。结论 DWI序列有助于早期预测和评估宫颈癌新辅助化疗疗效。

关键词: 磁共振, 弥散加权成像, 宫颈癌, 新辅助化疗

Abstract: Objective To analyze the value of diffusion weighted imaging(DWI)in assessing the effect of neoadjuvant chemotherapy of uterine cervix cancer.Methods Thirty one patients with LACC confirmed by pathology received conventional magnetic resonance imaging and DWI before and after neoadjuvant chemotherapy.The variation of DWI image and ADC was evaluated before and after chemotherapy.Results The correlation between maximum diameter of the tumor before treatment(37.10±11.23)and pretreatment ADC value(0.83±0.12)was not statistically significant(correlation coefficient r=-0.1746,P=0.3475);the correlation between the maximum diameter of the tumor(24.03±5.65)and ADC value(1.10±0.16)after treatment was not statistically significant(correlation coefficient r=-0.2077,P=0 2621.);the degree of tumor size before and after the treatment was correlated with the degree of ADC increase(P＜ 0.05);Effective chemotherapy group of 20 cases,invalid group of 11 cases,ADC value of effective treatment group after treatment(0.95±0.13)was significantly higher than ADC value before chemotherapy(0.80±0.12),the change was statistically significant(P＜0.05),while the difference between former ADC value(0.88±0.10)and ADC value after treatment(0.95±0.13)of ineffective group therapy was not statistically significant(P＞0.05).Conclusion DWI sequence may be useful for early prediction and evaluation of curative effect to neoadjuvant chemotherapy for uterine cervical cancer.

Key words: Magnetic resonance lmaging(MRI), Diffusion weighted imaging, Uterine cervix cancer, Neoadjuvant chemotherapy

中图分类号:

R445.2

巴志昌, 王欣欣, 崔万辉, 国飞, 张修石. MRI弥散加权成像对宫颈癌新辅助化疗评估的应用价值[J]. 实用肿瘤学杂志, 2015, 29(6): 518-522.

BA Zhichang, WANG Xinxin, CUI Wanhui, GUO Fei, ZHANG Xiushi. Value of diffusion weighted magnetic resonance imaging in the monitoring of neoadjuvant chemotherapy efficacy for uterine cervical cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 518-522.

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MRI弥散加权成像对宫颈癌新辅助化疗评估的应用价值

Value of diffusion weighted magnetic resonance imaging in the monitoring of neoadjuvant chemotherapy efficacy for uterine cervical cancer

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