结直肠肿瘤中长链非编码RNA的研究进展

doi:10.11904/j.issn.1002-3070.2015.06.016

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (6): 553-556.doi: 10.11904/j.issn.1002-3070.2015.06.016

结直肠肿瘤中长链非编码RNA的研究进展

张永健, 刘彦龙, 崔滨滨

哈尔滨医科大学附属肿瘤医院结直肠外科(哈尔滨 150081)

收稿日期:2015-04-15 出版日期:2015-12-28 发布日期:2015-12-28
通讯作者: 崔滨滨,E-mail:drcbb222@163.com E-mail:drcbb222@163.com
作者简介:张永健,男,(1989-),硕士研究生,从事结直肠癌基础与临床的研究

Progress in long non-coding RNA of colorectal cancer

ZHANG Yongjian, LIU Yanlong, CUI Binbin

Department of Colorectal Surgery,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-04-15 Online:2015-12-28 Published:2015-12-28

摘要/Abstract

摘要： 近年来许多长链非编码RNA(lncRNA)被发现,lncRNA表达量的异常与肿瘤的发生、发展密切相关,根据其作用可以分为促进肿瘤作用lncRNA和抑制肿瘤作用lncRNA,lncRNA普遍高表达于实体肿瘤内部,是参与肿瘤侵袭、增殖和转移的重要因素,且与肿瘤预后有关。本文介绍了目前lncRNA的研究现状,着重讲述了当前研究较为透彻的几个lncRNA(如:HOTAIR、H19、MALAT-1、LincRNA-p21、GAS5等)的功能及其在结直肠肿瘤组织中的表达情况,提示调控lncRNA表达量可能为结直肠肿瘤的诊断和治疗提供新的依据。

关键词: 长链非编码RNA(lncRNA), 结直肠肿瘤, 基因调控

Abstract: Many long non-coding RNA(lncRNA)has been found in recent years.The abnormal lncRNA expression is closely related to the occurrence and development of tumor.LncRNA can be divided into the tumor promoting and tumor inhibiting according to the function.lncRNA generally overexpresses in solid tumor tissue,acts as an important factor involved in tumor invasion,proliferation and metastasis,and has been associated with prognosis of neoplasm.This paper describes the current situation of lncRNA research.We mainly introduce several functions of lncRNA which thoroughly researched at present(such as HOTAIR,H19,MALAT-1,LincRNA-p21,GAS5,etc)and their expression in colorectal tumor tissue,indicating that regulating the expression level of lncRNA may provide a new basis for the diagnosis and treatment of colorectal cancer.

Key words: Long non-coding RNA(LncRNA), Colorectal cancer, Gene regulation

中图分类号:

R735.3⁺4

张永健, 刘彦龙, 崔滨滨. 结直肠肿瘤中长链非编码RNA的研究进展[J]. 实用肿瘤学杂志, 2015, 29(6): 553-556.

ZHANG Yongjian, LIU Yanlong, CUI Binbin. Progress in long non-coding RNA of colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 553-556.

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结直肠肿瘤中长链非编码RNA的研究进展

Progress in long non-coding RNA of colorectal cancer

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