5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察

doi:10.11904/j.issn.1002-3070.2016.05.003

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (5): 396-399.doi: 10.11904/j.issn.1002-3070.2016.05.003

5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察

周军敏¹, 戴绍春¹, 周森²

1.哈尔滨医科大学附属肿瘤医院(哈尔滨 150081);
2.黑龙江省医院

收稿日期:2016-05-25 出版日期:2016-10-28 发布日期:2016-11-02
通讯作者: 戴绍春,E-mail:daishaochun@yeah.net
作者简介:周军敏,女,(1983-),本科,住院医师,从事皮肤肿瘤的研究
基金资助:
黑龙江省博士后科研启动基金(LBH-Q15103)

Effect of 5-aminolevulinic acid mediated photodynamic therapy in combination with recombinant human interferon alpha 2b ointment on basal cell carcinoma in elderly

ZHOU Junmin¹, DAI Shaochun¹, ZHOU Sen²

1.Department of Dermatology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
2.Heilongjiang Provincial Hospital

Received:2016-05-25 Online:2016-10-28 Published:2016-11-02

摘要/Abstract

摘要： 目的探讨5-氨基酮戊酸光动力疗法(5-Aminolevulinic acid mediated photodynamic therapy,ALA-PDT)联合重组人干扰素α2b软膏治疗老年表浅基底细胞癌(Basal cell carcinoma,BCC)患者的疗效。方法选取143例BCC老年患者,随机分为PDT组(72例)和手术组(71例),PDT组采用ALA-PDT疗法联合干扰素治疗,手术组采取常规外科手术治疗,对两组患者的疗效、手术创伤面积、病变面积、复发情况、安全性等进行随访比较。结果 PDT组治疗后完全缓解率显著高于手术组(81.94% vs.57.75%,P＜0.05),而两组总有效率比较无统计学差异(91.66% vs.81.73%,P＞0.05);随访1年后,PDT组患者复发率显著低于手术组(9.72% vs.22.54%,P＜0.05);此外,PDT组平均创伤面积、治疗后病变面积也显著小于手术组(P＜0.05)。结论 ALA-PDT联合干扰素是一种临床疗效好,复发率低,创伤性小的治疗表浅基底细胞癌的有效方法。

关键词: 5-氨基酮戊酸, 光动力疗法, 干扰素, 表浅基底细胞癌

Abstract: Objective To evaluate the therapeutic effect of 5-aminolevulinic acid mediated photodynamic therapy(ALA-PDT)in combination with recombinant human interferon alpha 2b ointment on superficial basal cell carcinoma(BCC)in elderly.Methods A total of 143 elderly patients with superficial BCC was randomly divided into PDT group(n=72 cases)and the surgical group(n=71 cases).The patients in the two groups were given the ALA-PDT in combination with IFN-α2b and routine surgical treatment respectively.The efficacy after treatment was observed according to surgical wound area,lesion area,recurrence and security during 1 year follow-up.Results The Results displayed the complete remission rate of lesion in the PDT group was significantly higher than that in the surgical group(81.94% vs.57.75%,P＜0.05)after treatment,and the total effective rate of BCC was also higher than that in the surgical group,but no significant difference was identified in the two groups(91.66% vs.81.73%,P＞ 0.05).During 1 year follow-up after treatment,the Results showed the rate of recurrence in the PDT group was significantly lower than that in the surgical group(9.72% vs.22.54%,P＜0.05).Moreover,the mean wound area,the lesion area in the PDT group after treatment were also significantly smaller than that in the surgical group(P＜0.05).Conclusion ALA-PDT in combination with IFN is an effective method with lower recurrence and minor trauma in the treatment of superficial basal cell carcinoma.

Key words: 5-Aminolevulinic acid, Photodynamic therapy, Interferon, Superficial basal cell carcinoma

中图分类号:

R739.5

周军敏, 戴绍春, 周森. 5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察[J]. 实用肿瘤学杂志, 2016, 30(5): 396-399.

ZHOU Junmin, DAI Shaochun, ZHOU Sen. Effect of 5-aminolevulinic acid mediated photodynamic therapy in combination with recombinant human interferon alpha 2b ointment on basal cell carcinoma in elderly[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 396-399.

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5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察

Effect of 5-aminolevulinic acid mediated photodynamic therapy in combination with recombinant human interferon alpha 2b ointment on basal cell carcinoma in elderly

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