LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效

doi:10.11904/j.issn.1002-3070.2015.03.004

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 208-211.doi: 10.11904/j.issn.1002-3070.2015.03.004

LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效

里翠霜, 皮红, 黄进, 白芳

重庆市重钢总医院(重庆 400081)

收稿日期:2015-01-19 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 里翠霜 E-mail:350772950@qq.com
作者简介:里翠霜,女,(1975-),本科,主治医师,从事妇科学的研究

Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV

LI Cuishuang,PI Hong,HUANG Jin,BAI Fang

Department of Gynecology,Chonggang General Hospital,Chongqing 400081,China

Received:2015-01-19 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

目的观察并探讨宫颈环形电切术(LEEP)联合干扰素及重组人IL-2对宫颈上皮内瘤变Ⅱ(CIN Ⅱ)伴高危型HPV疗效的影响。方法选取2012年2月—2013年2月160例行LEEP术的CIN Ⅱ患者并随机分为四组(每组40例):对照组仅采用LEEP术治疗;A组采用LEEP术联合干扰素治疗;B组采用LEEP术联合重组人IL-2治疗;C组采用LEEP术联合干扰素及重组人IL-2治疗。治疗3个月、6个月后复查TCT、阴道镜及HPV,并对患者的疗效、并发症、HPV-DNA转阴率情况进行比较。结果 6个月后C组治愈率及HPV-DNA转阴率分别为92.5%、95%,高于其他三组(P＜0.05);与其他三组相比,C组创面愈合时间、阴道出血时间与阴道排液持续时间更短(P＜0.05)。结论 LEEP联合干扰素及白介素对CIN Ⅱ级伴高危型HPV的治疗效果明显优于单纯采用LEEP术及LEEP术单用干扰素或白介素,且愈合时间短,并发症较少,值得在临床上推广应用。

关键词: LEEP术, 干扰素, 重组人IL-2, 宫颈上皮内瘤变, 人乳头状瘤病毒

Abstract:

Objective To observe the therapeutic effect of cervical intraepithelial neoplasia Ⅱ(CIN Ⅱ)associated high risk HPV with LEEP combined interferon and recombinant human interleukin-2.Methods One hundred and sixty patients with CIN Ⅱ were selected during Feb.2012 and Feb.2013.The patients were randomly divided into four groups(40 patients in each group):the control group(LEEP),group A(LEEP united with interferon),group B(LEEP united with recombinant human interleukin-2)and group C(LEEP united with interferon and recombinant human interleukin-2).TCT,colposcope examination and HPV were reviewed,and the curative effects,postoperative complications and negative conversion rate of HPV-DNA were compared after three and six months of the treatment.Results The cure rate and negative conversion rate of HPV-DNA in group C were 92.5% and 95%,which were significantly higher than others groups(P＜0.05)after six months of treatment.The time of wound healing,duration of vaginal discharge and bleeding time in group C were also shorter than others groups(P＜0.05).Conclusion The therapeutic effect of LEEP combined with interferon and recombinant human interleukin-2 is superior to LEEP and LEEP united interferon or interleukin-2,which is not only shorter healing time,but also fewer complications.The therapeutic method is worthy to be applied widely.

Key words: Loop electrosurgical excision procedure, Interferon, Recombinant human interleukin-2, Cervical intraepithelial neoplasia, Human papillomavirus

中图分类号:

R737.33

里翠霜, 皮红, 黄进, 白芳. LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效[J]. 实用肿瘤学杂志, 2015, 29(3): 208-211.

LI Cuishuang,PI Hong,HUANG Jin,BAI Fang. Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 208-211.

参考文献

1 Vidal AC,Smith JS,Valea F,et al.HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA[J].Cancer Causes Control,2014,25(8):1055-1062.
2 Zubillaga-Guerrero MI,Illades-Aguiar B,Leyva-Vazquez MA,et al.The integration of HR-HPV increases the expression of cyclins A and E in cytologies with and without low-grade lesions[J].J Cytol,2013,30(1):1-7.
3 Witt BL,Factor RE,Jarboe EA,et al.Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion:frequency and clinical significance[J].Arch Pathol Lab Med,2012,136(10):1259-1261.
4 Gonzalez DI Jr,Zahn CM,Retzloff MG,et al.Recurrence of dysplasia after loop electrosurgical excision procedures with long-term follow-up[J].Am J Obstet Gynecol,2001,184(3):315-321.
5 吕玉璇,祝健婵,李焱.LEEP 联合人干扰素治疗宫颈上皮内瘤变伴高危型HPV疗效及预防复发的临床研究[J].中国妇幼保健,2014,(29):1126-1129.
6 乐杰,主编.妇产科学[M].北京:人民卫生出版社,2008:262-263.
7 吕佩瑾,鲁永鲜.妇科疾病诊断与疗效标准[M].上海:上海浦江教育出版社有限公司,2006:124-126.
8 Apgar B,Kaufman A,Bettcher C,et al.Gynecologic procedures:colposcopy,treatments for cervical intraepithelial neoplasia and endometrial assessment[J].Am Fam Physician,2013,87(12):836-843.
9 耿晓星,戴智莉,张海艳.青黛紫草合剂治疗上皮内瘤变的临床研究[J].实用肿瘤学杂志,2011,25(4):354-357.
10 李彩虹,陈建玲.LEEP术在宫颈癌前病变应用中的研究进展[J].实用肿瘤学杂志,2013,27(5):468-471.
11 Valerie PG,Thomas O,Kiran R,et al.A Phase Ⅱ trial of bevacizumab and high dose interferon alpha-2B in metastatic melanoma[J].J Immunother,2011,34(6):509-515.
12 Mardegan MC,Ramos MC,Adad SJ,et al.Immunological evaluation of vaginal secretion in patients with high-grade cervical intraepithelial neoplasia treated with intralesional interferon alpha-2b[J].Eur J Gynaecol Oncol,2011,32(3):297-302.
13 Wei L,Jian-Xin L,Warren JL.Interleukin-2 at the crossroads of effector responses,tolerance,and immunotherapy[J].Immunity,2013,38(1):13-25.
14 陈霞.宫颈电圈切除术联合重组人白介素-2治疗宫颈上皮内瘤样病变的临床观察[J].实用中西医结合临床,2011,11(5):46-47.

[1]	付艳丽, 余杨, 卫玮, 邹晶晶, 孙翔. 高危型人乳头状瘤病毒载量和Th1/Th2不均衡表达预测宫颈癌变进程的研究[J]. 实用肿瘤学杂志, 2018, 32(6): 533-537.
[2]	雷蕾, 叶庆华, 王国增, 黄贤莉, 吴乾渝. Aurora-A在宫颈癌及癌前病变中的表达以及与HPV感染的相关性研究[J]. 实用肿瘤学杂志, 2017, 31(6): 494-499.
[3]	教玉颖综述, 付鹏审校. 甲状腺癌与干扰素-γ、白介素-6关系的研究进展[J]. 实用肿瘤学杂志, 2017, 31(1): 88-92.
[4]	周军敏, 戴绍春, 周森. 5-氨基酮戊酸光动力疗法联合重组人干扰素α2b软膏治疗老年患者表浅基底细胞癌的临床观察[J]. 实用肿瘤学杂志, 2016, 30(5): 396-399.
[5]	李彩虹综述,陈建玲审校. LEEP术在宫颈癌前病变应用中的研究进展[J]. 实用肿瘤学杂志, 2013, 27(5): 468-471.
[6]	童英, 刘露, 李春东, 任东平. ILK及E-钙黏蛋白的表达在宫颈鳞癌发病中的意义[J]. 实用肿瘤学杂志, 2011, 25(5): 431-436.
[7]	夏百荣, 孟凡玲, 卢北燕. mTOR、eIF4E、4E-BP1在宫颈癌组织中的表达及临床意义[J]. 实用肿瘤学杂志, 2011, 25(4): 301-305.
[8]	高玉华, 高岩, 汤巍巍, 王硕. 高载量HR-HPV感染与宫颈癌及其癌前病变关系的研究[J]. 实用肿瘤学杂志, 2010, 24(1): 53-55.
[9]	王敏. 人乳头状瘤病毒感染、P16^INK4A及PCNA在宫颈上皮内瘤变中的意义[J]. 实用肿瘤学杂志, 2009, 23(3): 245-248.
[10]	魏晓丽;许静洪;成延萍. 子宫颈癌及癌前病变组织中p53基因产物表达与HPV感染的关系[J]. 实用肿瘤学杂志, 2006, 20(06): 523-524,.
[11]	陈莉;李奕;王彦. 宫颈上皮内瘤变及早期宫颈癌术中冰冻病理诊断及临床意义[J]. 实用肿瘤学杂志, 2005, 19(02): 141-142.
[12]	张建国;史海军;程远合;马建新;鲁功成. α-2b干扰素加顺铂预防膀胱癌术后复发的远期疗效[J]. 实用肿瘤学杂志, 2004, 18(02): 97-100.
[13]	甄珍;程丽坤;郑冬梅. 宫颈上皮内瘤变的阴道镜检查[J]. 实用肿瘤学杂志, 2003, 17(01): 72-72.
[14]	陆海波;孙秀威;于雁. 25例多发性骨髓瘤的诊治分析[J]. 实用肿瘤学杂志, 2002, 16(04): 303-304.
[15]	宋福山;于淑侠;王立波. 干扰素联合丝裂霉素治疗恶性胸腔积液的临床观察[J]. 实用肿瘤学杂志, 2001, 15(04): 286-286.

LEEP术联合干扰素及重组人白介素-2对宫颈上皮内瘤变伴高危型HPV的疗效

Effect of LEEP combined interferon and recombinant human interleukin-2 on CIN associated high-risk HPV

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价