VDR基因FokI位点多态性与结直肠癌易感性之间关系的Meta分析

doi:10.11904/j.issn.1002-3070.2016.05.004

摘要/Abstract

摘要： 目的对VDR中FokI位点与结直肠癌关系作简要探讨。方法对由确定的准入标准纳入文献进行评估,以表格的形式对提取的数据进行归纳,然后对数据进行异质性检验,并由固定或随机效应模型进行Meta分析。结果本研究共纳入15篇实验研究,包括7859例结直肠癌患者与9933例对照组。FokI隐性基因模型合并为ff与FF+Ff的对比,隐性模型的OR值为1.01(95% CI=0.87~1.17,I²=54%,P=0.91),显性模型的OR值为0.94(95% CI=0.83~1.06,I²=64%,P=0.30),等位基因模型f与F的对比中OR值为0.98(95% CI=0.89~1.08,I²=71%,P=0.72)。亚组分析隐性基因模型白色人种OR值为0.95(95% CI=0.86~1.05,I²=0%,P=0.33),黄色人种OR值为1.12(95% CI=0.77~1.63,I²=72%,P=0.54),亚组分析显性基因模型白色人种OR值为0.95(95% CI=0.86~1.04,I²=27%,P=0.29),黄色人种OR值为0.89(95% CI=0.65~1.22,I²=78%,P=0.47),亚组分析等位基因模型白色人种OR值为0.97(95% CI=0.90~1.04,I²=31%,P=0.38),黄色人种OR值为1(95% CI=0.79~1.27,I²=82%,P=1.00)。结论 VDR基因中FokI位点不论F或f等位基因均与结直肠癌之间无明显的直接关联,在亚洲人群与高加索人群中无差别。但仍然需用广泛的实验研究来进一步确定在其他人群中的结论。

关键词: 结直肠癌, VDR, Meta分析

Abstract: Objective To discuss the relationship between FokI gene polymorphism and colorectal cancer.Method The references that met the inclusive criteria were assessed.The extracted data were summarized in the form of tables.Data were analyzed by heterogeneity test.Meta-analysis was conducted by using fixed effects model or random effects model.Results Fifteen experimental studies were included in this study,including 7,859 colorectal cancer patients and 9,933 controls.The association between VDR gene FokI and colorectal cancer was expressed as the odds ratio(OR)and 95% confidence interval(CI).FokI recessive genetic model,ff versus FF+ Ff,ORrecessive=1.01(95% CI=0.87~1.17,I²=54%,P=0.91),ORdominant=0.94(95% CI=0.83~1.06,I²=64%,P=0.30);allele model,fversus F,OR=0.98(95% CI=0.89~1.08,I²=71%,P=0.72).In subgroup analysis,recessive genetic model,ORCaucasian race=0.95(95% CI=0.86~1.05,I²=0%,P=0.33);ORyellow race=1.12(95% CI=0.77~1.63,I²=72%,P=0.54).In subgroup analysis,dominant gene model,ORCaucasian race=0.95(95% CI=0.86~1.04,I²=27%,P=0.29);ORyellow race=0.89(95% CI=0.65~1.22,I²=78%,P=0.47).In subgroup analysis,allele model,ORCaucasian race=0.97(95% CI=0.90~1.04,I²=31%,P=0.38);ORyellow race=1(95% CI=0.79~1.27,I²=82%,P=1.00).Conclusion Our Results suggested that in VDR gene FokI,F and f alleles were not obviously directly correlated with colorectal cancer.No difference was found between Asian and Caucasian.The Conclusions in other populations should be further identified by extensive experimental studies.

Key words: Colorectal cancer, VDR, Meta-analysis

中图分类号:

R-1
R735.3

崔君鹏, 刘宝林. VDR基因FokI位点多态性与结直肠癌易感性之间关系的Meta分析[J]. 实用肿瘤学杂志, 2016, 30(5): 400-408.

CUI Junpeng, LIU Baolin. Association between VDR gene FokI polymorphism and colorectal cancer susceptibility:a meta-analysis[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 400-408.

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