细胞凋亡在原发性肝癌治疗中的作用研究进展

doi:10.11904/j.issn.1002-3070.2016.05.013

摘要/Abstract

摘要： 原发性肝癌是最为常见的恶性肿瘤之一。传统治疗方法包括早期手术切除、化疗和放疗,但总体治疗效果较差,最主要原因之一可能是肝癌细胞凋亡信号通路阻断。本文对RA、STAT3、PDT、p53、β-catenin、TRAIL、microRNA和RAS等关键凋亡信号通路和PDT在诱导肝癌细胞凋亡中的作用研究进展进行综述,进一步明确这些凋亡信号通路在肝癌治疗中的作用,以期找到特异性诱导肝癌细胞凋亡的靶点,为细胞凋亡治疗肝癌的发展提供有益线索。

关键词: 细胞凋亡, 肝癌, 信号转导, 靶向治疗

Abstract: Hepatocellular carcinoma(HCC)is one of the commonest malignant tumors in China.The therapeutic effects of conventional therapies including surgery resection at early stage,chemotherapy or radiotherapy are greatly less than expected.One of the most possible reasons is the blockage of apoptosis in HCC cells.This review collects literatures about the studies on the roles of key signal pathways including RA,STAT3,PDT,p53,β-catenin,TRAIL,microRNA and RAS in HCC therapy.This study may contribute greatly to providing outline insights for using apoptosis induction in liver cancer therapy.We hope it can promote the development liver cancer therapy in China.

Key words: Apoptosis, HCC, Signal pathway, Target therapy

中图分类号:

R735.7

赵相轩, 温锋, 毛晓楠综述, 卢再鸣审校. 细胞凋亡在原发性肝癌治疗中的作用研究进展[J]. 实用肿瘤学杂志, 2016, 30(5): 448-452.

ZHAO Xiangxuan, WEN Feng, MAO Xiaonan, LU Zaiming. Study advances on the roles of apoptosis in hepatocellular carcinoma therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 448-452.

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