叉头框蛋白M1在乳腺癌的进展及治疗耐药中的作用

doi:10.11904/j.issn.1002-3070.2016.05.015

摘要/Abstract

摘要： 叉头框蛋白质M1(Forkhead box protein M1,FoxM1)是一种特异性的与增殖相关的转录因子。既往研究发现,FoxM1具有增强癌细胞增殖、转移和侵袭的功能,在肿瘤的发生发展中扮演着至关重要的角色。近年来研究表明,FoxM1的异常表达在乳腺癌的发生及发展中起着重要的作用,且其过表达与肿瘤患者的总生存期的关系呈负相关,为乳腺癌的早期诊断、临床预后及联合治疗提供了新的研究方向,本文就FoxM1与乳腺癌的关系做一综述。

关键词: FoxM1, 转录因子, 乳腺癌, 治疗

Abstract: FoxM1 is a specific transcription factor related to proliferation.Previous studies have found that FoxM1 can enhance the proliferation,metastasis and invasion of cancer cells,and play a crucial role in cancer.Recent studies indicate that the abnormal expression of FoxM1 plays an important role in breast cancer,and its overexpression is negatively correlated with the overall survival of patients.For the early diagnosis of breast cancer,clinical prognosis and study on combination therapy provides a new direction.This article reviews the relationship between FoxM1 and breast cancer.

Key words: FoxM1, Transcription factor, Breast cancer, Therapy

中图分类号:

R737.9

李蕙颖综述, 耿敬姝审校. 叉头框蛋白M1在乳腺癌的进展及治疗耐药中的作用[J]. 实用肿瘤学杂志, 2016, 30(5): 458-462.

LI Huiying, GENG Jingshu. The role of FoxM1 in the development and treatment of breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 458-462.

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