MTBP与癌症的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.017

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (6): 560-562.doi: 10.11904/j.issn.1002-3070.2016.06.017

MTBP与癌症的研究进展

李根英¹，综述，张云艳²，审校

1.哈尔滨医科大学(哈尔滨 150081)；
2.哈尔滨医科大学附属肿瘤医院妇放科

收稿日期:2016-07-28 出版日期:2016-12-31 发布日期:2016-12-27
通讯作者: 张云艳,E-mail:zhangyunyan-1972@163.com
作者简介:李根英，女，(1989-)，硕士研究生，从事宫颈癌放疗增敏的研究
基金资助:
哈医大附属肿瘤医院海燕基金重点项目(JJZD2014-07)

Research progress of MDM2-binding protein in cancer

LI Genying¹,ZHANG Yunyan²

1.Harbin Medical University,Harbin 150081,China;
2.Department of Gynecological Radiotherapy,The Affiliated Tumor Hospital of Harbin Medical University

Received:2016-07-28 Online:2016-12-31 Published:2016-12-27

摘要/Abstract

摘要： 鼠双微体2癌基因结合蛋白(MDM2-binding protein，MTBP)是鼠双微体2(Murine double minute 2，MDM2)的结合蛋白，并参与调节细胞的代谢、增殖及凋亡等生物学过程。近年来研究发现MTBP在多种恶性肿瘤中出现表达异常，其表达的异常与恶性肿瘤的增殖、侵袭转移、发生、发展及预后关系密切。MTBP可能成为多种恶性肿瘤治疗的潜在靶点。本文将MTBP在恶性肿瘤中的研究做一简要综述。

关键词: MTBP, 癌症, 进展, 预后

Abstract: MDM2-binding protein(MTBP)factor is a binding protein of MDM2,and MDM2 gene and involved in the development of cancer as an important gene,which has been studied for a long time.It has been demonstrated that MTBP could regulate biological processes such as metabolism,growth,and apoptosis of cells.In the past few years,some studies have found that MTBP is down-regulated in variety of malignancies,which is associated with the progression and the prognosis of these tumors.MTBP may be a potential target for the treatment of many kinds of malignant tumors.This paper reviews the research pregressof MDM2-binding protein on cancer.

Key words: MTBP, Cancer, Progress, Prognosis

中图分类号:

李根英，综述，张云艳，审校. MTBP与癌症的研究进展[J]. 实用肿瘤学杂志, 2016, 30(6): 560-562.

LI Genying,ZHANG Yunyan. Research progress of MDM2-binding protein in cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 560-562.

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MTBP与癌症的研究进展

Research progress of MDM2-binding protein in cancer

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