锌离子转运体LIV-1在食管鳞癌中的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.020

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (6): 572-576.doi: 10.11904/j.issn.1002-3070.2016.06.020

• 综述 • 上一篇

锌离子转运体LIV-1在食管鳞癌中的研究进展

周士祥，综述，李多杰，审校

蚌埠医学院第一附属医院放疗科(蚌埠 233000)

收稿日期:2016-04-19 出版日期:2016-12-31 发布日期:2016-12-27
通讯作者: 李多杰,E-mail:liduojie@163.com
作者简介:周士祥，男，(1989-)，硕士研究生，从事肿瘤放疗方向的研究

The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma

ZHOU Shixiang,LI Duojie

Department of Radiation Oncology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China

Received:2016-04-19 Online:2016-12-31 Published:2016-12-27

摘要/Abstract

摘要： LIV-1，也称为SLC39A6/ZIP6，是锌转运蛋白ZIP家族中LZT亚家族成员之一，主要定位于细胞膜，包含有6~8个跨膜结构域，富含组氨酸残基，参与胚胎发育、肿瘤发生和发展等过程。有研究表明，LIV-1在食管鳞状细胞癌预后中具有重要作用，被证实与预后呈负相关，过表达影响预后，且其可能是一个潜在的治疗靶点。本文将对锌离子转运蛋白LIV-1与食管鳞癌的相关研究进展进行综述。

关键词: LIV-1, ZIP6, SLC39A6, 锌离子转运蛋白, 食管鳞癌

Abstract: LIV-1(SLC39A6/ZIP6),primarily located on the cell membrane,is one of the LZT subfamily members among the zinc transportprotein family.It possess six to eight transmembrane spanning domains,with regions of concentrated histidine residues,which has been shown to participate in the process of embryonic development as well as the growth and proliferation of tumors.It has been clearly established that LIV-1 played an important role in the development of esophageal squamous cell carcinoma and its overexpression,which turned out to be a negative correlation upon the cancer′s prognosis has been verified to be a potent therapeutic target.Herein,the advances of zinc transporter LIV-1 and the potential significance of the transporter to esophageal squamous cell carcinoma are reviewed.

Key words: LIV-1, ZIP6, SLC39A6, Zinc transportprotein, Esophageal squamous cell carcinoma

中图分类号:

R735.1

周士祥，综述，李多杰，审校. 锌离子转运体LIV-1在食管鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2016, 30(6): 572-576.

ZHOU Shixiang,LI Duojie. The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 572-576.

参考文献

1 陈万青,郑容寿,张思维,等.2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8.
2 Chen W,Zheng R,Baade PD,et al.Cancer statistics in china,2015[J].CA Cancer,2016,66(2):115-132.
3 Wu C,Li D,Lin D,et al.Genome wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous cell carcinoma[J].Nat Genet,2013,45(6):632-638.
4 Manning DL,Daly RJ,Lord PG,et al.Effects of oestrogen on the expression of a 44 kb mRNA in the ZR-75-1 human breast cancer cell line[J].Mol Cell Endocrinol,1988,59(3):205-212.
5 Jiang Y,Zhang S,Feng S,et al.Genome wide identification,phylogeny and expression of zinc transporter genes in common carp[J].PLoS One,2014,9(12):e116043.
6 Grattan BJ,Freake HC.Zinc and cancer:implications for LIV-1 in breast cancer[J].Nutrients,2012,4(7):648-675.
7 Taylor KM,Nicholson RI.The LZT proteins;the LIV-1 subfamily of zinc transporters[J].Biochimica Et Biophysica Acta,2003,1611(1/2):16-30.
8 Liu Y,Batchuluun B,Ho L,et al.Characterization of zinc influx transporters(ZIPs)in pancreatic beta cells:Roles in regulating cytosolic zinc homeostasis and insulin secretion[J].J Biol Chem,2015,290(30):18757-18769.
9 Wong CP,Rinaldi NA,Ho E.Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation[J].Mol Nutr Food Res,2015,59(5):991-999.
10 Wong CP,Magnusson KR,Ho E.Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation[J].J Nutr Biochem,2013,24(1):353-359.
11 Ho E,Dukovcic S,Hobson B,et al.Zinc transporter expression in zebrafish(Danio rerio)during development[J].Comp Biochem and Physiol,2012,155(1):26-32.
12 Wen J,Luo KJ,Liu QW,et al.The epithelial-mesenchymal transition phenotype of metastatic lymph nodes impacts the prognosis of esophageal squamous cell carcinoma patients[J].Oncotarget,2016,7(25):37581-37588.
13 Pang L,Li Q,Li S,et al.Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma:Observations from clinical and in vitro analyses[J].Sci Rep,2016,6:22179.
14 Kalluri R.EMT:when epithelial cells decide to become mesenchymal-like cells[J].J Clin Invest,2009,119(6):1417-1419.
15 Zhao L,Chen W,Taylor KM,et al.LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway[J].Biochem Biophys Res Commun,2007,363(1):82-88.
16 Lue HW,Yang X,Wang R.et al.LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling[J].PLoS One,2011,6(11):e27720.
17 Hogstrand C,Kille P,Ackland ML,et al.A mechanism for epithetlial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3(signal transducer and activator of transcription 3)[J].Biochem J,2013,455(2):229-237.
18 李栋.遗传变异与食管癌和小细胞肺癌生存的关联研究[D].北京:北京协和医院,2013.
19 Cui XB,Shen YY,Jin TT,et al.SLC39A6:a potential target for diagnosis and therapy of esophageal carcinoma[J].J Transl Med,2015,13(1):321.
20 Jin J,Li Z,Liu J,et al.Knockdown of zinc transporter ZIP5(SLC39A5)expression significantly inhibits human esophageal cancer progression[J].Oncol Rep,2015,34(3):1431-1439.
21 Harada K,Baba Y,Ishimoto T,et al.The role of microRNA in esophageal squamous cell carcinoma[J].J Gastroenterol,2016,51(6):520-530.
22 Chandler P,Kochupurakkal BS,Alam S,et al.Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer[J].Mol Cancer,2016,15(1):2.
23 Sussman D,Smith LM,Anderson ME,et al.SGN-LIV1A:a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer[J].Mol Cancer Ther,2014,13(12):2991-3000.
24 Unno J,Masamune A,Hamada S,et al.The zinc transporter LIV-1 is a novel regulator of stemness in pancreatic cancer cells[J].Scand J Gastroenterol,2014,49(2):215-221.
25 Lian J,Jing Y,Dong Q,et al.miR-192,a prognostic indicator,targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma[J].Oncotarget,2016,7(3):2672-2683.
26 Antala S,Ovchinnikov S,Kamisetty H,et al.Computation and functional studies provide a model for the structure of the zinc transporter hZIP4[J].J Biol Chem,2015,290(29):17796-17805.

[1]	张群综述，李多杰审校. PD-1/PD-L1在食管鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(3): 250-253.
[2]	杨留勤, 武莉萍, 赵春霞, 陈利军, 张如楠, 黄海航, 任民柱. RUNX3与OPN在食管鳞癌组织中的表达及其临床意义[J]. 实用肿瘤学杂志, 2010, 24(4): 378-381.
[3]	吴晁;陈同钰;孟凡青;樊祥山. 癌-睾丸抗原NY-ESO-1在食管鳞状细胞癌中的表达及其意义[J]. 实用肿瘤学杂志, 2007, 21(01): 18-20.

锌离子转运体LIV-1在食管鳞癌中的研究进展

The research advances of zinc transporter LIV-1 in esophageal squamous cell carcinoma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

本文评价