雌激素受体相关受体γ在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.01.017

摘要/Abstract

摘要： 雌激素受体相关受体γ(ERRγ)是孤儿核受体家族(NRs)的成员之一,可在无天然配体存在时转录调控多种基因的表达,在维持细胞的基本生物学活动中发挥重要作用。近年来,越来越多的研究显示ERRγ参与肿瘤的发生发展过程,包括肿瘤细胞代谢、增殖、转移以及血管生成等。而ERRγ在肿瘤进展及预后中的作用具有细胞和组织特异性,本文就ERRγ在肿瘤中的临床相关性及其作用机制进行综述,为代谢、雌激素相关肿瘤发生及靶向治疗提供理论依据。

关键词: 雌激素受体相关受体γ, 肿瘤, 代谢, 增殖, 转移

Abstract: Estrogen receptor-related receptor γ(ERR γ)belongs to the orphan nuclear receptor family(NRs),which can regulate the expression of multiple genes in the absence of natural ligands and play an important role in maintaining the basic biological activities of cells.In recent years,the data from many studies have shown that ERR γ is involved in the development and progression of tumor,including tumor cell metabolism,proliferation,metastasis and angiogenesis.Besides,the effect of ERR γ on tumor progression and prognosis has the specificity of cell and tissue.This paper will review the clinical significance of ERR γ and its mechanism in metabolism and tumors related estrogen ,which provided the theoretical basis for metabolism and estrogen-related tumorigenesis and targeted therapy.

Key words: Estrogen receptor-related receptor γ, Tumor, Metabolism, Proliferation, Metastasis

中图分类号:

王笑笑, 华腾, 汪宏波. 雌激素受体相关受体γ在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(1): 87-91.

WANG Xiaoxiao, HUA Teng, WANG Hongbo. Research progress of estrogen receptor-related receptor γ in tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 87-91.

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