孤儿核受体在前列腺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2018.04.019

摘要/Abstract

摘要： 孤儿核受体(Orphan nuclear receptor,ONRs)是指没有配体或尚未发现配体的核受体,研究发现它在许多关键生理过程中起着重要的调节作用,由这些受体异常调控导致的信号失调常引起包括癌症在内的多种疾病。前列腺癌是泌尿生殖系统恶性肿瘤中最常见的类型之一,高发病率、复发率和死亡率是其代名词;虽然早期预后良好,但中晚期患者生活质量及预后仍然很差;作为转化医学研究的热点,近年来在中晚期前列腺癌诊断、治疗方面已经取得了不错的进展。本文就ONRs在前列腺癌方面作用机制及临床相关性方面的研究进展做一综述,为前列腺癌的发生、发展、侵袭、转移及治疗等方面提供一定的理论依据。

关键词: 孤儿核受体, 核受体, 前列腺癌, 基因转录表达

Abstract: Orphan nuclear receptors(ONRs)refer to nuclear receptors without ligands or unknown ligands.It has been found to an important regulatory role in many key physiological processes,resulting from the control of these receptors.But signal disorders often cause many diseases including cancer.Prostate cancer is one of the most common types of malignant tumors in the urogenital system.High morbidity,recurrence rate and mortality are synonymous.Although the early prognosis is good,the quality of life and prognosis are still poor in patients with advanced disease.As a hotspot in translational medicine research,good progress has been made in the diagnosis and treatment of advanced prostate cancer in recent years.This article reviews the research progress of ONRs in the mechanism and clinical relevance of prostate cancer,and provides a theoretical basis for the occurrence,development,invasion,metastasis and treatment of prostate cancer.

Key words: Orphan nuclear receptor, Nuclear receptor, Prostate cancer, Gene transcription expression

中图分类号:

R697

姜涛, 张旭. 孤儿核受体在前列腺癌中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 377-380.

JIANG Tao,ZHANG Xu. The research progress of orphan nuclear receptors in prostate cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 377-380.

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