TACC3和p53蛋白在原发性肝癌组织中的表达及其临床意义

doi:10.11904/j.issn.1002-3070.2018.05.007

摘要/Abstract

摘要： 目的探讨TACC3蛋白和p53蛋白在原发性肝癌组织中的表达及其临床意义。方法本院原发性肝癌患者138例,酶联免疫吸附法及免疫组化法测定癌旁组织、原发性肝癌组织中TACC3、p53蛋白的表达水平,分析其与临床病理参数和预后的关系。结果原发性肝癌组TACC3蛋白、p53蛋白表达水平高于癌旁组(P＜0.05);原发性肝癌组TACC3、p53阳性率高于癌旁组(P＜0.05);TACC3、p53蛋白表达与年龄无关(P＞0.05);与TMN分期、病理学分级、复发、浸润深度、淋巴血管间隙浸润、肿瘤最大径、淋巴结转移有关,且TNM分期越高、病理学分期越高、有复发、浸润深度越深、有淋巴血管间隙浸润、肿瘤最大径≥5 cm、有淋巴结转移,TACC3、p53蛋白阳性表达率越高(P＜0.05);TACC3、p53阴性组3年生存率均明显高于TACC3、p53阳性组(P＜0.01)。结论原发性肝癌组织中TACC3、p53蛋白表达量增加,其与原发性肝癌的进展呈正相关;TACC3、p53蛋白低表达能提高原发性肝癌患者预后。

关键词: TACC3, p53, 原发性肝癌

Abstract: Objective The aim of this study was to investigate the expression and clinical significance of TACC3 protein and p53 protein in primary liver cancer.Methods A total of 138 patients with primary liver cancer were enrolled in this study.The expression of TACC3 and p53 protein in normal tissues and primary liver cancer tissues were determined by enzyme-linked immunosorbent assay and immunohistochemistry.The relationships between the expression of TACC3 and p53 protein,and the clinicopathological parameters and prognosis were analyzed.Results The expression of TACC3 protein and p53 protein in primary liver cancer group was higher than those in the paracancerous group(P＜0.05).The positive rates of TACC3 and p53 in primary hepatocellular carcinoma group were higher than that in the paracancerous group(P＜0.05).The expression of TACC3 and p53 protein was not correlated with age(P＞0.05),but they were positively correlated with the TNM stage,pathological grade,recurrence,depth of invasion,lymphatic vascular infiltration,maximum diameter of tumor(≥5 cm)and lymph node metastasis(P＜0.01).The higher TNM stage,the pathological stage recurrence,deeper infiltration,lymphatic vascular infiltration,maximum tumor diameter ≥5 cm and lymph node metastasis,the higher TACC3 and p53 protein expression(P＜0.05).The 3-year survival rates in the negative expression TACC3 and p53 group were significantly higher than that in the positive expression of TACC3 and p53 positive groups(P＜0.01).Conclusion TACC3 and p53 proteins play an important role in the development of primary liver cancer.The expression of TACC3 and p53 protein in primary liver cancer tissues is increased.The low expression of TACC3 and p53 protein can significantly improve the prognosis of patients with primary liver cancer.

Key words: TACC3, p53, Primary hepatocellular carcinoma

中图分类号:

R735.7

贺伟, 母齐鸣, 王刚, 万波, 廖波, 杨娟. TACC3和p53蛋白在原发性肝癌组织中的表达及其临床意义[J]. 实用肿瘤学杂志, 2018, 32(5): 420-425.

HE Wei, MU Qiming, WANG Gang, WAN Bo, LIAO Bo, YANG Juan. Expression of TACC3 and p53 protein in primary liver cancer and its clinical significance[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 420-425.

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