铁皮石斛抑制上皮源性恶性肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2020.04.013

摘要/Abstract

摘要： 铁皮石斛作为我国传统中药材,有着逆转氧化、抗疲劳、调节免疫、降糖等功效。近年来,铁皮石斛在抗肿瘤方面的作用更是受到了广泛的关注。研究结果表明,铁皮石斛可以通过多种机制或通路作用于上皮源性的恶性肿瘤。通过调节DNA损伤、降低炎症因子的表达等多种方式预防癌症发生,以阻滞癌细胞周期、抑制肿瘤血管生成、诱导癌细胞凋亡等方式抑制上皮源性肿瘤的生长。相比于放化疗药物严重的毒副作用,铁皮石斛更天然更安全,使得铁皮石斛新药和新产品的创新具有广阔的前景。本文从铁皮石斛抑制上皮源性恶性肿瘤的大量研究资料出发,综述了大量的国内外研究进展,为铁皮石斛进一步的研发和应用提供依据。

关键词: 铁皮石斛, 癌症, 抑制作用, 细胞凋亡

Abstract: Dendrobium officinale,as a traditional Chinese medicinal material in China,has the effects of reversing oxidation,anti-fatigue,regulating immunity and reducing blood sugar.In recent years,the role of dendrobium officinale in antitumor has attracted widespread attention.The results from many studies show that dendrobium officinale can act on the inhibitory effects on epithelial-derived malignant tumors through a variety of mechanisms or pathways.The growth of epithelial-derived malignant tumors can be inhibited by regulating DNA damage,reducing the expression of inflammatory factors and other ways to prevent cancer,block cancer cell cycle,inhibit tumor angiogenesis,and induce cancer cell apoptosis ways.Compared with the serious toxic and side effects of chemoradiotherapy drugs,dendrobium officinale is more natural and safer,which makes the innovation of new drug and product of dendrobium officinale have broad prospects.Based on a large amount of research data from the inhibition of epithelial-derived malignant tumors by dendrobium officinale,this paper reviews a large number of domestic and foreign research advances,and provides a basis for further development and application of dendrobium officinale.

Key words: Dendrobium officinale, Cancer, Inhibitory effect, Apoptosis

中图分类号:

庞晨, 张秀玲, 张锡流. 铁皮石斛抑制上皮源性恶性肿瘤的研究进展[J]. 实用肿瘤学杂志, 2020, 34(4): 362-367.

PANG Chen, ZHANG Xiuling, ZHANG Xiliu. Research progress in inhibitory epithelium-derived malignant tumors by dendrobium officinale[J]. Journal of Practical Oncology, 2020, 34(4): 362-367.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.04.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I4/362

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