术前疲乏状态与中晚期肝细胞癌患者术后生活质量的关联性:一项前瞻性队列研究

doi:10.11904/j.issn.1002-3070.2022.02.005

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (2): 127-132.doi: 10.11904/j.issn.1002-3070.2022.02.005

术前疲乏状态与中晚期肝细胞癌患者术后生活质量的关联性:一项前瞻性队列研究

庞春华, 李繁荣, 唐如冰, 覃蕾, 赵新华, 唐娟, 游雪梅

广西医科大学附属肿瘤医院肝胆外科(南宁 530021)

收稿日期:2021-12-30 修回日期:2022-03-23 出版日期:2022-04-28 发布日期:2022-04-28
通讯作者: 游雪梅,E-mail:youxuemei@stu.gxmu.edu.cn
作者简介:庞春华,女,(1982-),硕士研究生,主管护师,从事肿瘤心理学方面的研究。
基金资助:
国家自然科学基金(编号:81960308)

Association between preoperative fatigue status and postoperative quality of life in patients with advanced hepatocellular carcinoma:a prospective cohort study

PANG Chunhua, LI Fanrong, TANG Rubing, QIN Lei, ZHAO Xinhua, TANG Juan, YOU Xuemei

Department of Hepatobiliary Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China

Received:2021-12-30 Revised:2022-03-23 Online:2022-04-28 Published:2022-04-28

摘要/Abstract

摘要： 目的探讨中晚期肝癌患者术前疲乏与术后生活质量的关联性。方法选取2019年9月—2021年8月在广西医科大学附属肿瘤医院首次接受手术治疗的144例中晚期肝癌患者为研究对象。采用简易疲乏量表、生活质量核心量表对患者进行调查,了解中晚期肝癌患者术前疲乏发生情况和术后1个月的生活质量,并分析两者关联性。结果术前无疲乏患者41例(28.5%),轻度疲乏患者61例(42.4%),中重度疲乏患者42例(29.1%)。轻度疲乏组和中重度疲乏组总体健康水平及各功能领域得分均低于无疲乏组,差异具有统计学意义(P＜0.05);中重度疲乏组总体健康水平及各功能领域得分均低于轻度疲乏组,差异具有统计学意义(P＜0.05)。多重线性回归分析显示,患者术前疲乏状态与术后总体生活质量及各功能领域得分呈负相关。结论中晚期肝癌患者术前疲乏程度越高,术后生活质量越差,医护人员应在术前对患者的疲乏症状采取积极有效的干预措施,优化术前状态,以提高患者术后生活质量。

关键词: 中晚期肝癌, 疲乏, 生活质量

Abstract: Objective The of this study was to investigate the relationship between preoperative fatigue and postoperative quality of life in patients with advanced hepatocellular carcinoma.Methods A total of 144 patients with advanced hepatocellular carcinoma who received surgery for the first time in the Affiliated Tumor Hospital of Guangxi Medical University from September 2019 to August 2021 were selected as the research subjects.The patients were investigated with the Simple Fatigue Scale and the Quality of Life Core Scale to understand the preoperative fatigue and the quality of life after operation for one month in patients with advanced liver cancer,and to analyze the association between two groups.Results There were 41 patients(28.5%)without preoperative fatigue,61 patients(42.4%)with mild fatigue,and 42 patients(29.1%)with moderate to severe fatigue.The overall health level and the scores of various functional areas in the mild fatigue group were lower than those in the no-fatigue group,and the differences were statistically significant(P＜0.05).The overall health level and scores of each functional area in the moderate to severe fatigue group were lower than those in the mild fatigue group,and the differences were statistically significant(P＜0.05).Multiple linear regression analysis showed that preoperative fatigue status was negatively correlated with postoperative overall quality of life and scores in various functional areas.Conclusion The higher the degree of preoperative fatigue in patients with advanced hepatocellular carcinoma,the poorer the postoperative quality of life.Medical staff should take active and effective intervention measures for the patients' fatigue symptoms before surgery,optimize the preoperative status,and improve the postoperative life quality of the patients.

Key words: Advanced hepatocellular carcinoma, Fatigue, Quality of life

中图分类号:

R735.7

庞春华, 李繁荣, 唐如冰, 覃蕾, 赵新华, 唐娟, 游雪梅. 术前疲乏状态与中晚期肝细胞癌患者术后生活质量的关联性:一项前瞻性队列研究[J]. 实用肿瘤学杂志, 2022, 36(2): 127-132.

PANG Chunhua, LI Fanrong, TANG Rubing, QIN Lei, ZHAO Xinhua, TANG Juan, YOU Xuemei. Association between preoperative fatigue status and postoperative quality of life in patients with advanced hepatocellular carcinoma:a prospective cohort study[J]. Journal of Practical Oncology, 2022, 36(2): 127-132.

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参考文献

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
2 李秋林,曹骥,容敏华,等.2016年广西肿瘤登记地区恶性肿瘤发病和死亡分析[J].中国癌症防治杂志,2020,12(1):44-51.
3 Llovet JM,Kelley RK,Villanueva A,et al.Hepatocellular carcinoma[J].Nat Rev Dis Primers,2021,7(1):6.
4 Noy MA,Rich B J,Llorente R,et al.Levels of evidence for radiation therapy recommendations in the National Comprehensive Cancer Network(NCCN)clinical guidelines[J].Adv Radiat Oncol,2022,7(1):1-7.
5 Behringer K,Goergen H,Müller H,et al.Cancer-related fatigue in patients with and survivors of hodgkin lymphoma:the impact on treatment outcome and social reintegration[J].J Clin Oncol,2016,34(36):4329-4337.
6 Jung JY,Lee JM,Kim MS,et al.Comparison of fatigue,depression,and anxiety as factors affecting posttreatment health-related quality of life in lung cancer survivors[J].Psychooncology,2018,27(2):465-470.
7 Zhou J,Sun H,Wang Z,et al.Guidelines for the diagnosis and treatment of hepatocellular carcinoma(2019 Edition)[J].Liver Cancer,2020,9(6):682-720.
8 Wang XS,Hao XS,Wang Y,et al.Validation study of the chinese version of the brief fatigue inventory(BFI-C)[J].J Pain Symptom Manage,2004,27(4):322-332.
9 Mendoza TR,Wang XS,Cleeland CS,et al.The rapid assessment of fatigue severity in cancer patients:use of the Brief Fatigue Inventory[J].Cancer,1999,85(5):1186-1196.
10 万崇华,陈明清,张灿珍,等.癌症患者生命质量测定量表EORTC QLQ-C30中文版评介[J].实用肿瘤杂志,2005,20(4):353-355.
11 Schmidt ME,Hermann S,Arndt V,et al.Prevalence and severity of long-term physical,emotional,and cognitive fatigue across 15 different cancer entities[J].Cancer Med,2020,9(21):8053-8061.
12 Paulsen Ø,Laird B,Aass N,et al.The relationship between pro-inflammatory cytokines and pain,appetite and fatigue in patients with advanced cancer[J].PLoS One,2017,12(5):e177620.
13 赵凌云,韦珏伶,赵新华,等.巴塞罗那(BCLC)B/C期肝癌患者术前抑郁相关因素分析及对免疫功能的影响[J].现代肿瘤医学,2018,26(11):1727-1732.
14 宋均仿,叶雪梅,彭梦苗.心理护理对肝癌患者癌疲乏性、负面情绪及生活质量的影响[J].护理实践与研究,2016,13(22):147-148.
15 赵凤娟,王琪,任贇虹,等.肝癌伴抑郁患者血清CRP、hs-CRP水平变化及其对预后的影响[J].实用肿瘤学杂志,2019,33(1):27-33.
16 Verma M,Paik JM,Younossi I,et al.The impact of hepatocellular carcinoma diagnosis on patients′ health-related quality of life[J].Cancer Med,2021,10(18):6273-6281.
17 Pearson E,Morris ME,McKinstry CE.Cancer related fatigue:implementing guidelines for optimal management[J].BMC Health Serv Res,2017,17(1):496.

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术前疲乏状态与中晚期肝细胞癌患者术后生活质量的关联性:一项前瞻性队列研究

Association between preoperative fatigue status and postoperative quality of life in patients with advanced hepatocellular carcinoma:a prospective cohort study

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