Abstract: Objective To observe the effect of concurrent chemoradiotherapy plus adjuvant chemotherapy in patients with advanced cervical squamous cell carcinoma.Method 156 cases with stage Ⅱa-Ⅲb cervical squamous cell carcinoma were randomly divided into both the concurrent chemoradiotherapy group(experimental group)and radiotherapy group(control group).Radiotherapy was administered by intracavity and external beam radiation therapy,dose of point A were given for 40Gy-48Gy/10f-12f and dose of point B for 46Gy-50Gy/23f-25f.In the same time,experimental group was treated by DDP 40 mg/d 1,3,5 intravenous drip,repeated every week.Tenth day after radiation therapy,adjuvant chemotherapy using TP program was given three times,21 days intervally.Results The short-term efficiency for the experimental group and the control group was 88.61% and 75.33% respectively (P＜0.05).In one year to three year after treatment,the overall survival rate(OS)and distance metastasis free survival rate(DMF)and local recurrence free(LRF)for the experimental group were different significantly (P＜0.05)than the control group.Quality of life of were significantly improved after treatment.Lack of appetite,diarrhea and blood toxicity of the treatment modalities were observed as limiting toxicity(P＜0.05).Conclusion Concurrent chemoradiotherapy plus adjuvant chemotherapy for advanced cervical cancer patients can improve short-term and quality of life,the limiting toxicity can be tolerated.