关键词: 胰腺癌, 发病率, 死亡率, 变化趋势, 肿瘤登记, 甘肃

Abstract: Objective The Objective of this study was to analyze the epidemiological characteristics and changing trends of incidence and mortality of pancreatic cancer in cancer registration areas of Gansu province from 2009 to 2015,and provide the evidence for enacting prevention and treatment measures of pancreatic cancer.Methods According to the audit methods and standards established by the National Cancer Registration Center,the pancreatic cancer data reported by 11 cancer registration areas in Gansu province were evaluated.The incidence and mortality,age-standardized incidence/mortality rates by Chinese standard population(ASR China)and by World standard population(ASR World),the cumulative rate of 0~74 years old and composition were calculated by area,sex and age groups.The annual percentage change(APC)was used to analyze the time trend of the incidence and mortality by Chinese standard population of pancreatic cancer.Results From 2009 to 2015,there were 1 963 new cases of pancreatic cancer in Gansu cancer registration areas.The incidence of pancreatic cancer in the cancer registration areas of Gansu province was 5.18/100 000(6.01/100 000 in male,4.31/100 000 in female),the age-standardized incidence rates by Chinese standard population and by World standard population were 4.67/100 000 and 5.44/100 000.In the same period,there were 1 708 deaths.The mortality was 4.51/100 000(5.26/100 000 in male,3.72/100 000 in female),the age-standardized mortality rates by Chinese standard population and by World standard population were 3.78/100 000 and 4.49/100 000.The incidence and mortality by Chinese standard population in rural areas(5.32/100 000,4.63/100 000)were higher than those of in urban areas(4.60/100 000,3.54/100 000).The incidence and mortality of pancreatic cancer increased with age,which was higher in male than those in female.From 2009 to 2015,the incidence and mortality by Chinese standard population of pancreatic cancerin Gansu province showed a steady(APC=-4.2%,t=-1.6,P=0.2 and APC=-3.6%,t=-1.1,P=0.1).Conclusion From 2009 to 2015,the incidence and mortality of pancreatic cancer in Gansu province showed a stable trend,but they were higher in rural areas than those in urban areas.Among them,middle-aged and elderly men are the key population for the prevention and control of pancreatic cancer.The etiological research and early diagnosis of pancreatic cancer should be strengthened to effectively control the occurrence and development of pancreatic cancer.

Key words: Pancreatic cancer, Incidence, Mortality, Change trend, Cancer registration, Gansu