铜死亡在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2024.01.008

摘要/Abstract

摘要： 铜是生物体内不可缺少的一种微量元素,生理状态下在细胞内维持一定的水平。铜死亡是一种独特、铜依赖性的细胞死亡,是极为重要的一种调节性细胞死亡(Regulated cell death,RCD),且不同于现阶段已知的其他细胞死亡形式。越来越多的研究表明,铜死亡对肿瘤细胞的代谢途径转换、信号通路传导、蛋白质的加工与修饰均有着不可忽视的影响。铜死亡相关lncRNA也被广泛用于预测肿瘤的预后。铜死亡可以抑制肿瘤细胞生长,并可作为控制耐药和疾病复发的潜在靶点。本文对铜死亡在肿瘤发生发展中的作用机制进行综述。

关键词: 铜死亡, 肿瘤, 细胞死亡, 调节性细胞死亡

Abstract: Copper is an indispensable trace element in living organisms and maintains at a certain level in cells under physiological conditions.Cuprotosis is a unique,copper-dependent cell death.It is an extremely important type of regulated cell death(RCD)and is different from other forms of cell death currently known.More and more studies have shown that cuprotosis has a non-negligible impact on the metabolic pathway transition,signaling pathway transduction,and protein processing and modification of tumor cells.Cuprotosis-related lncRNAs are also widely used to predict tumor prognosis.Cuprotosis can inhibit tumor cell growth and serve as a potential target for controlling drug resistance and disease recurrence.This article reviews the mechanism of cuprotosis in the development and progression of tumor cells.

Key words: Cuprotosis, Tumor, Cell death, Regulated cell death

中图分类号:

R737.9

高源, 唐钰涵, 王露, 赵文辉. 铜死亡在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2024, 38(1): 50-54.

GAO Yuan, TANG Yuhan, WANG Lu, ZHAO Wenhui. Research progress of cuprotosis in tumors[J]. Journal of Practical Oncology, 2024, 38(1): 50-54.

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