人乳头瘤病毒与宫颈病变的相关性研究

doi:10.3969/j.issn.1002-3070.2009.03.007

实用肿瘤学杂志 ›› 2009, Vol. 23 ›› Issue (3): 225-227.doi: 10.3969/j.issn.1002-3070.2009.03.007

人乳头瘤病毒与宫颈病变的相关性研究

牛淑芳¹, 刘志强¹, 吴素慧², 魏学功¹

1.山东滨州医学院附属医院(滨州 256603);
2.山西医科大学第一附属医院

收稿日期:2008-11-10 出版日期:2009-03-25 发布日期:2012-02-21
作者简介:牛淑芳, 女, (1973-), 硕士, 主治医师, 从事妇科肿瘤研究

The research of the correlation between human papillomavirus and cervical lesions

NIU Shufang, LIU Zhiqiang, WU Suhui, WEI Xuegong

The Affiliated Hospital of Binzhou Medical College, Binzhou 256603

Received:2008-11-10 Online:2009-03-25 Published:2012-02-21

摘要/Abstract

摘要： 目的探讨宫颈病变与HPV DNA基因型感染的关系。方法导流杂交基因分型技术检测HPV DNA。结果炎症、CINI、CINII、CINIII及宫颈癌中HPV感染率分别为62.24%、67.64%、91.67%、96.87%、96.00%;宫颈病变中6种最常见的HPV基因型为16、18、52、58、33、31。炎症、CINI、CINII、CINIII及宫颈癌患者多重感染率分别为19.0%、35.8%、45.9%、54.9%、60.8%、70.2%。结论随宫颈病变程度加重HPV感染率增加, 宫颈病变中6种最常见HPV基因型为16、18、52、58、33、31。多重HPV感染可能促进宫颈癌的发生。

Abstract: Objective To investigste the correlation between the positive rate of HPV genetypes and the severity of cervical lesions.Methods Flow-through Hybridization was employed to detect the positive rate of high-risk HPV and the genetypes of HPV in cervical lesions.Results The positive rate of HPV test in cervicitis, CINI, CINII, CINIII and cervical cancer were 43.87%, 64.70%, 91.67%, 93.75% and 96% respectively.The most common genetypes in cervical lesions were HPV 16, 18, 52, 58, 33 and 31.The positive rate of multiplicitas genetypes infection in cervicitis, CINI, CINII, CINIII and cervical cancer were 35.8%, 45.9%, 54.9%, 60.8% and 70.2% respectively.Conclusions The positive rate increased with the process developing of cervical lesions.The most common genetypes in cervical lesions were HPV16, 18, 52, 58, 33 and 31.There were more multiplicitas genetypes with the development of cervical lesions.

中图分类号:

牛淑芳, 刘志强, 吴素慧, 魏学功. 人乳头瘤病毒与宫颈病变的相关性研究[J]. 实用肿瘤学杂志, 2009, 23(3): 225-227.

NIU Shufang, LIU Zhiqiang, WU Suhui, WEI Xuegong. The research of the correlation between human papillomavirus and cervical lesions[J]. PRACTICAL ONCOLOGY JOURNAL, 2009, 23(3): 225-227.

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人乳头瘤病毒与宫颈病变的相关性研究

The research of the correlation between human papillomavirus and cervical lesions

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