ELISA法检测血清EB病毒VCA-IgA对喉癌早期筛查的价值

doi:10.3969/j.issn.1002-3070.2012.02.003

实用肿瘤学杂志 ›› 2012, Vol. 26 ›› Issue (2): 106-108.doi: 10.3969/j.issn.1002-3070.2012.02.003

ELISA法检测血清EB病毒VCA-IgA对喉癌早期筛查的价值

姚鸿超, 王超, 李秋影, 王宇, 冯佳鹏, 肖辉, 肖玉丽

哈尔滨医科大学附属第二医院耳鼻咽喉头颈外科(哈尔滨 150086)

收稿日期:2011-09-15 出版日期:2012-04-28 发布日期:2014-12-03
通讯作者: 王超,E-mail:hljwangchao@yahoo.com.cn
作者简介:姚鸿超,女,(1977-),博士,副教授,从事喉癌的基础与临床研究
基金资助:
哈尔滨市科技局青年科技创新人才基金(2007RFQXS081)

Value of detection of serum Epstein-Barr virus VCA-IgA by ELISA technique for early diagnosis of laryngeal carcinoma

YAO Hongchao,WANG Chao,LI Qiuying,WANG Yu,FENG Jiapeng,XIAO Hui,XIAO Yuli

Department of Otolaryngology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086

Received:2011-09-15 Online:2012-04-28 Published:2014-12-03

摘要/Abstract

摘要： 目的评估血清检测EB病毒VCA-IgA对喉癌早期筛查的价值。方法 ELISA法检测喉癌患者48例、健康成人48例,血清EB病毒VCA-IgA。结果喉癌患者组VCA-IgA阳性率为68.75%,而健康成人组VCA-IgA阳性率仅为2.08%。29例无颈淋巴结转移者与19例有颈淋巴结转移者之间,VCA-IgA阳性率无统计学差异。26例临床早期患者(Ⅰ期和Ⅱ期)和22例晚期患者(Ⅲ期和Ⅳ期之间)VCA-IgA阳性率亦无统计学差异。结论 ELISA法检测血清VCA-IgA有助于喉癌的早期筛查,但不能作为判断预后的指标。

关键词: ELISA法, EB病毒VCA-IgA, 喉癌

Abstract: Objective To evaluate the value of detection of serum Epstein-Barr virus(EBV)VCA-IgA by ELISA technique for early diagnosis of laryngeal carcinoma.Methods Serum EBV VCA-IgA was detected by ELISA technique in 48 laryngeal carcinoma patients and 48 healthy adults.Results The positive rates of serum EBV VCA-IgA were 68.75% of laryngeal carcinoma patients and 2.08% of healthy adults,respectively.The positive rate of serum EBV VCA-IgA in 29 patients without neck lymph node metastasis was not significantly different from that in 19 patients with neck lymph node metastasis.There was also no significant difference of positive rate of serum EBV VCA-IgA between 26 early stage patients(stage Ⅰ and Ⅱ)and 22 advanced stage patients(stage Ⅲ and Ⅳ).Conclusion The detection of serum EBV VCA-IgA by ELISA technique could be used as early diagnosis of laryngeal carcinoma,but not as an prognosis indicator.

Key words: ELISA technique, Epstein-Barr virus VCA-IgA, Laryngeal carcinoma

中图分类号:

R739.65

姚鸿超, 王超, 李秋影, 王宇, 冯佳鹏, 肖辉, 肖玉丽. ELISA法检测血清EB病毒VCA-IgA对喉癌早期筛查的价值[J]. 实用肿瘤学杂志, 2012, 26(2): 106-108.

YAO Hongchao,WANG Chao,LI Qiuying,WANG Yu,FENG Jiapeng,XIAO Hui,XIAO Yuli. Value of detection of serum Epstein-Barr virus VCA-IgA by ELISA technique for early diagnosis of laryngeal carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2012, 26(2): 106-108.

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ELISA法检测血清EB病毒VCA-IgA对喉癌早期筛查的价值

Value of detection of serum Epstein-Barr virus VCA-IgA by ELISA technique for early diagnosis of laryngeal carcinoma

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