Abstract: Objective According to different technology,to evaluate of the quality of survival liver cancer patients with radiation.Methods From March 2009 to July 2010,22 patents from two independent prospective studies were included in the analysis.12 patients were treated by three dimensional conformal radiotherapy ,and 10 patients by Image Guided Radiation Therapy.CBCT images were got with Elekta CBCT+ABC system before treatment and registered with plan CT images according the margins of tumor target.The results were recorded before CBCT.After treatment,we got CBCT images and do the registration,got CBCT.The results were analyzed with SPSS.Results According to Stroom formula ,when without correcting of dose ,the margins of CTV-PTV with IGRT were X=0.3cm、Y=0.4cm and Z=0.2cm respectively;The margins of CTV-PTV without IGRT were X=0.8cm、Y=0.9cm and Z=0.9cm respectively.The 1- and 2-year survival rates were 58.3%,16.7% and 70% ,20%,respectirely.The respective median survivals were 12 months and 16 months.Conclusions With the IGRT,the margin of CTV-PTV was diminished by 5mm.As the soft organ,the whole liver has different passion during the organ moving.Just using the margin of liver as the registration point,moving in the organ is inestimable,and there will be uncertain in image registration.IGRT is safe and effective for liver cancer patients.The short-term effect is satisfactory.