实用肿瘤学杂志 ›› 2012, Vol. 26 ›› Issue (4): 328-335.doi: 10.3969/j.issn.1002-3070.2012.04.010

• 论著 • 上一篇    下一篇

心理社会危险因素与大肠癌的相关性研究

李丹丹1, 胡付兰1, 朱琳1, 王彝白娜1, 刘宇鹏1, 陈王洋1, 崔滨滨2, 赵亚双1   

  1. 1.哈尔滨医科大学公共卫生学院流行病学教研室(哈尔滨 150086);
    2.哈尔滨医科大学附属第三医院腹外科
  • 收稿日期:2011-12-02 出版日期:2012-08-28 发布日期:2014-12-03
  • 通讯作者: 赵亚双,E-mail:zhao_yashuang@263.net
  • 作者简介:李丹丹,女,(1983-),博士,从事大肠癌的分子流行病学研究

The relationship between psychosocial risk factors and colorectal cancer

LI Dandan1,HU Fulan1,ZHU Lin1,WANG Yibainai1,LIU Yupeng1,CHEN Wangyang1,CUI Binbin2,ZHAO Yashuang1   

  1. 1.Department of Epidemiology,Public Health College,Harbin Medical University,Harbin 150086;
    2.Department of Abdominal Surgery,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081
  • Received:2011-12-02 Online:2012-08-28 Published:2014-12-03

摘要: 目的 探讨个性行为特征、情绪状态和生活事件等心理社会因素与大肠癌发生的相关性,为更有效的防治大肠癌提供科学依据。方法 采用以医院为基础的病例-对照研究,病例组256人和对照组488人采用团体用心理社会应激调查表对其生活事件、情绪反应及应对方式三方面进行测评。结果 多因素Logistic回归结果显示人际关系不协调(OR=32.245)、子女前途问题(OR=3.773)、个人健康状况变化(OR=1.655)、着急(OR=1.894)、遇事压到心底(OR=3.300)和苦恼时喜欢一个人独处(OR=1.928)是大肠癌的危险因素。而心情愉快(OR=0.310)和遇事换个环境排解(OR=0.194)为大肠癌的保护性因素。结论 某些负性生活事件、消极的情绪及应对方式均与大肠癌的发病有关,而常保持心情愉快与遇事乐观态度会降低大肠癌的发病几率。

Abstract: Objective To investigate the relationship between psychosocial risk factors and colorectal cancer.Methods A hospital based case-control study of colorectal cancer was conducted.Cases were pathologically confirmed as primary cancers of the colon and rectum.Both 256 cases and 488 controls were tested by the PSSG scale.Results Multivariate conditional logistic regression analysis showed that interpersonal disharmony(OR=32.245),children′s future(OR=3.773),changes in individual health status(OR=1.655),anxious emotion(OR=1.894)and like being alone when distressed(OR=1.928)might increase the risk of colorectal cancer;pleasing emotion(OR=0.310)and resolving problems for the environment(OR=0.194)can protect for colorectal cancer.Conclusion Psychosocial stressful factors(such as stressful life events,introversive psychological reactions and negative coping styles)are one of the important risk factors in the onset of colorectal cancer.

中图分类号: