Abstract: Objective To investigate the expression of Ezrin in hepatocellular carcinoma and the relationship between Ezrin and epithelial mesenchymal transition of hepatocellular carcinoma.Methods By maxvision immunohistochemical method,we determined the expressions of Ezrin,E-cad and Vimentin and the relationship between them in 60 specimens of hepatocellular carcinoma and 30 specimens of nomal hepatic tissues.Results The positive rate of Ezrin in hepatocellular carcinoma was significantly higher than that in the normal tissue(60% vs 7%,P＜0.01).The positive rate of E-cad inhepatocellular carcinoma tissue was lower than that in the normal tissue(43% vs 76.6%,P＜0.01).The positive rate of Vimentin in carcinoma was higher than that in the normal tissue(43.7% vs 0%,P＜0.01).Ezrin overexprossion was correlated with the clinical stage(P＜0.05).The Spearman correlation analysis demonstrated that Ezrin expression wag negatively correlated with E-cad expression,while it was positively correlated with Vimentin expression.Conclusion Ezrin may play a crucial role in the progression of hepatocellular carcinoma and correlate with epithelial mesenchymal transition.