实用肿瘤学杂志 ›› 2012, Vol. 26 ›› Issue (6): 559-563.doi: 10.3969/j.issn.1002-3070.2012.06.019

• 综述 • 上一篇    下一篇

新抑癌基因——TSLC1和DAL-1/4.1B与恶性肿瘤的关系

张艳伟, 马晓欣   

  1. 中国医科大学附属盛京医院妇产科(沈阳 110004)
  • 收稿日期:2012-08-28 出版日期:2012-12-28 发布日期:2014-12-03
  • 通讯作者: 马晓欣,E-mail:maxiaoxin666@yahoo.com.cn
  • 作者简介:张艳伟,女,(1984-),硕士研究生,从事妇科肿瘤研究
  • 基金资助:
    辽宁省教育厅资助课题(L2010642);辽宁省科学技术厅资助课题(20102266)

New tumor suppressor gene ——TSLC1 and DAL-1/4.1B relationship with cancer

ZHANG Yanwei,MA Xiaoxin   

  1. Department of gynaecdogy and obstetrics,Shengjing Hospital of China Medical University,Shenyang 110004,China
  • Received:2012-08-28 Online:2012-12-28 Published:2014-12-03

摘要: 肺癌肿瘤抑制物基因1(tumor suppressor of non-small cell lung cancer 1/TSLC1)和肺腺癌差异表达因子4.1B(differentially expressed in adenocarcinoma of the lung/4.1B,DAL-1/4.1B)均是近年新发现的抑癌基因,具有潜在的肿瘤抑制作用。研究表明二者在多种组织中都有表达,而且在许多肿瘤中均表现为表达减低或表达缺失。肿瘤的浸润程度、转移程度和疾病预后情况与抑癌基因的表达与否密切相关,抑癌基因失活的主要可能机制之一是基因启动子发生甲基化。二者可作为新的肿瘤标志物,指导肿瘤的早期诊断及靶基因治疗。

Abstract: TSLC1 and DAL-1/4.1 B are new found in recent years of tumor suppressor genes,with potential tumor of inhibition.Research shows that both in a variety of organizations were expressed,and many tumors are performance for lower expression or missing.Gene inactivation is relevant with the extensive of the tumor,transfer and prognosis.One of the main possible mechanism of the gene inactivation is gene promoter methylation.Both can be used as new tumor markers,guiding the early detection of cancer and target gene therapy.

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