Agrin参与恶性肿瘤发生发展的研究现状

doi:10.11904/j.issn.1002-3070.2023.06.009

实用肿瘤学杂志 ›› 2023, Vol. 37 ›› Issue (6): 507-512.doi: 10.11904/j.issn.1002-3070.2023.06.009

Agrin参与恶性肿瘤发生发展的研究现状

赵世博, 陈永峰, 黎惠怡综述, 符爱珍审校

广东医科大学附属医院妇产科(湛江 524000)

收稿日期:2023-06-25 修回日期:2023-10-02 出版日期:2023-12-28 发布日期:2024-03-18
通讯作者: 符爱珍,E-mail:Faizhen1@126.com
作者简介:赵世博,女,(1996-),硕士研究生,从事妇科肿瘤的研究。
基金资助:
湛江市科技发展专项资金竞争性分配项目(编号:220826174543328)

Research status of Agrin involvement in the occurrence and development of malignant tumors

ZHAO Shibo, CHEN Yongfeng, LI Huiyi, FU Aizhen

Department of Obstetrics and Gynecology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China

Received:2023-06-25 Revised:2023-10-02 Online:2023-12-28 Published:2024-03-18

摘要/Abstract

摘要： 恶性肿瘤已成为威胁人类健康的第一大疾病,全球恶性肿瘤发病率逐年上升,目前晚期和复发患者生存质量差和耐药的问题愈加明显。减少肿瘤的侵袭与转移、提高肿瘤患者的生存及预后是肿瘤治疗中亟待解决的难题。集聚蛋白(Agrin)是一种与神经突触形成相关的膜蛋白,近年来的研究证实Agrin在肿瘤发生发展中发挥着重要的作用。Agrin表达于恶性肿瘤和免疫细胞中,在肿瘤血管生成、细胞增殖、迁移、化疗耐药和中性粒细胞浸润中发挥着重要的调控作用。本文就Agrin的研究现状,特别是其在恶性肿瘤发生发展中的相关作用及机制进行总结与分析。

关键词: 集聚蛋白, 恶性肿瘤, 信号通路

Abstract: Malignant tumor has become the largest disease threatening human health.The global incidence of cancer is increasing year by year.At present,the poor quality of life and drug resistance of patients with advanced and recurrent cancer are becoming increasingly obvious.Reducing the invasion and metastasis of tumor,improving the survival and prognosis of tumor patients,are urgent problems to be solved in tumor treatment.Agrin is a membrane protein associated with synaptic formation,and recent studies have shown that Agrin plays an important role in the occurrence and development of tumors.Agrin is expressed in malignant tumors and immune cells,playing an important regulatory role in tumor angiogenesis,cell proliferation and migration,chemotherapy resistance,and neutrophil infiltration.This article summarizes and analyzes the current research status of Agrin,especially its related role and mechanism in the occurrence and development of malignant tumors.

Key words: Agrin, Malignant tumor, Signaling pathway

中图分类号:

R730.2

赵世博, 陈永峰, 黎惠怡, 符爱珍. Agrin参与恶性肿瘤发生发展的研究现状[J]. 实用肿瘤学杂志, 2023, 37(6): 507-512.

ZHAO Shibo, CHEN Yongfeng, LI Huiyi, FU Aizhen. Research status of Agrin involvement in the occurrence and development of malignant tumors[J]. Journal of Practical Oncology, 2023, 37(6): 507-512.

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Agrin参与恶性肿瘤发生发展的研究现状

Research status of Agrin involvement in the occurrence and development of malignant tumors

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