Abstract: Objective To observe the effect of anti-angiogenesis drug Endostar on the expressions of hypoxia inducible factor-1α(HIF-1α)and glucose transporter-1(GLUT-1).Methods The transplantation tumor models of Lewis lung carcinoma were randomly divided into 4 groups,namely control group,ES group,RT group and ES+RT group.We measured the longest diameter of the tumor(a)and shortest diameter(b).The tumor volume was calculated by V=ab2/2.The tumor body was for detection.Detection was performed by western blot method.Results (1)There was significant difference between ES+RT group and ES group(P＜0.05).The combined group inhibited the best.(2)ES+RT group decreased obviously compared with ES group and RT group.The difference was statistically significant(P＜0.05).RT group,compared with ES group,is lower with statistics differences(P＜0.05).(3)ES+RT group has statistical significance(P＜0.05).ES group,the difference was not significant(P＞0.05).There was significant difference between group RT and group ES+RT(P＜0.05).(4)HIF-1α was positively correlated with GLTU-1 expression(P＜0.01).Conclusion Endostar combined with radiotherapy can inhibit Lewis mice tumor growth.Endostar can improve the hypoxic tumor which inhibiting the expression of HIF-1α and GLTU-1.It may be one of the mechanism for increasing radiosensitization.