II期结肠腺癌组织P-STAT5蛋白表达及其临床意义

doi:10.3969/j.issn.1002-3070.2013.03.014

实用肿瘤学杂志 ›› 2013, Vol. 27 ›› Issue (3): 251-255.doi: 10.3969/j.issn.1002-3070.2013.03.014

II期结肠腺癌组织P-STAT5蛋白表达及其临床意义

毛银玲,曹宇星,项亚光,娄长杰,李志伟,张艳桥

哈尔滨医科大学附属肿瘤医院消化内科(哈尔滨 150040)

收稿日期:2013-01-17 出版日期:2013-06-28 发布日期:2013-07-04
通讯作者: 张艳桥,E-mail:yanqiaozhang@126.com
作者简介:毛银玲,女,(1976-),博士,副主任医师,从事消化道肿瘤的诊治研究
基金资助:
黑龙江省教育厅科学技术研究项目(11551295)

Study on expression and clinical value of P-STAT5 in stage II colonic adenocarcinoma

MAO Yinling,CAO Yuxing,XIANG Yaguang,LOU Changjie,LI Zhiwei,ZHANG Yanqiao

Department of Gastrointestinal Medical Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2013-01-17 Online:2013-06-28 Published:2013-07-04

摘要/Abstract

摘要： 目的探讨P-STAT5蛋白在Ⅱ期结肠腺癌组织中的表达情况及其与Ⅱ期结肠腺癌患者的临床病理特征和预后生存的关系。方法采用免疫组织化学SP法检测122例Ⅱ期结肠腺癌组织标本中P-STAT5蛋白的表达情况。结果 P-STAT5蛋白表达定位于细胞质;P-STAT5蛋白表达与肿瘤分化程度相关(P=0.033);P-STAT5蛋白阳性表达与更短预后生存相关(P=0.047,Log-rank test),但不是Ⅱ期结肠腺癌独立的预后判定指标(P=0.053,HR:2.41)。结论 P-STAT5蛋白的表达与Ⅱ期结肠腺癌患者预后相关,检测P-STAT5的表达可能对Ⅱ期结肠腺癌患者术后辅助治疗的选择有参考价值。

Abstract: Objective STAT5 activation(Phospho-STAT5,P-STAT5)has been observed in a variety of human tumors.Many studies have found that poor prognosis is associated with the expression of phospho-STAT5.However,it is not clear how activated STAT5 is expressed in colon cancer.In this study,we aimed to investigate phospho-STAT5 expression and its relationship with clinicopathological factors and overall survival in Stage Ⅱ colonic adenocarcinoma.Methods 122 histological samples of Stage Ⅱ colonic adenocarcinoma were selected for this study.Immunohistochemistry was used to detect the expression of phospho-STAT5.Results Phospho-STAT5 expression was observed in the cytoplasm of colonic adenocarcinoma cells.A significant relationship was found between phospho-STAT5 expression and tumour differentiation(P=0.033).Univariate analysis showed that shorter overall survival was correlated with phospho-STAT5 immunoreactivity(P=0.047,log-rank test).Multivariate analysis showed that phospho-STAT5 was not an independent predictor in relation with shorter overall survival(P=0.053,hazard ratio=2.41).Conclusion Expression of phospho-STAT5 is correlated with shorter survival in patients with Stage Ⅱ colonic adenocarcinoma.It may be of great value in evaluating the expression of phospho-STAT5 for adjuvant systemic therapy in surgically treated patients with Stage Ⅱ colonic adenocarcinoma.

中图分类号:

R735.3⁺5

毛银玲,曹宇星,项亚光,娄长杰,李志伟,张艳桥. II期结肠腺癌组织P-STAT5蛋白表达及其临床意义[J]. 实用肿瘤学杂志, 2013, 27(3): 251-255.

MAO Yinling,CAO Yuxing,XIANG Yaguang,LOU Changjie,LI Zhiwei,ZHANG Yanqiao. Study on expression and clinical value of P-STAT5 in stage II colonic adenocarcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2013, 27(3): 251-255.

[1]	辛鹤, 王传卓, 刘兆玉. microRNA-196a与肿瘤相关性的研究进展[J]. 实用肿瘤学杂志, 2018, 32(1): 42-46.
[2]	苗绘, 朱龙图, 许芝林, 赵铮, 王继洲. 过表达von Hippel-Lindau蛋白抑制小鼠结肠癌的生长及肝转移的研究[J]. 实用肿瘤学杂志, 2016, 30(5): 385-390.
[3]	薛伟男,张干,杨艳梅,马玉彦,孙根,崔滨滨. 抑癌基因ING1在大肠癌中的表达及预后意义[J]. 实用肿瘤学杂志, 2014, 28(5): 385-390.
[4]	张建锋, 武雪亮, 王贵英, 周超熙, 牛文博, 席金川. 结肠癌D3清扫术后乳糜漏的危险因素分析[J]. 实用肿瘤学杂志, 2013, 27(4): 323-327.
[5]	杨东东,武雪亮,何琨,王立坤. 结肠癌D3清扫术后腹腔乳糜漏的病因预防及治疗分析[J]. 实用肿瘤学杂志, 2013, 27(2): 120-123.
[6]	梁欢, 崔宝红, 王影, 梁影, 彭士云. Sp1和Survivin在结肠癌中的表达及意义[J]. 实用肿瘤学杂志, 2012, 26(4): 348-353.
[7]	郑文鑫, 韩艳玲, 魏海波, 张晓金, 姜鹏宇, 吕雪莹. 奥沙利铂与7-羟基星形孢菌素对结肠癌HCT116细胞的杀伤作用及其机制的研究[J]. 实用肿瘤学杂志, 2012, 26(3): 199-203.
[8]	吕丽艳, 韩波, 关景明, 赵春波. Survivin、Ki-67和COX-2在结直肠腺瘤旁鸡皮样黏膜中的表达及意义[J]. 实用肿瘤学杂志, 2010, 24(5): 422-424.
[9]	张松岩, 徐海涛, 肖敏, 黄孙卉. 谷氨酰胺对术后早期腹腔化疗的结肠吻合口愈合的影响[J]. 实用肿瘤学杂志, 2009, 23(3): 235-237.

II期结肠腺癌组织P-STAT5蛋白表达及其临床意义

Study on expression and clinical value of P-STAT5 in stage II colonic adenocarcinoma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 9

编辑推荐

Metrics

本文评价