Abstract: Wnt/β-catenin signal transduction pathway has a close relationship with many human cancers.β-catenin is an essential regulatory factor in Wnt/β-catenin signal transduction pathway.For the past few years, it has received more and more attention in pathogenesis of hepatocellular carcinoma.The current review discusses biological function of β-catenin and the relationship between the expression of β-catenin and the proliferation, invasion and metastasis of hepatocellular carcinoma, especially the research progress in the hypoxia microenvironment.It provides theoretical basis for intensive pathogenesis of hapatocellular carcinoma and targeting therapy.