卵巢癌肿瘤微环境的三维细胞培养模型研究进展

doi:10.11904/j.issn.1002-3070.2019.06.016

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (6): 557-560.doi: 10.11904/j.issn.1002-3070.2019.06.016

卵巢癌肿瘤微环境的三维细胞培养模型研究进展

张慧婷综述, 娄阁审校

哈尔滨医科大学附属肿瘤医院妇科(哈尔滨 150081)

收稿日期:2018-12-21 修回日期:2019-01-22 发布日期:2019-12-28
通讯作者: 娄阁,E-mail:dr-louge@163.com
作者简介:张慧婷,女,(1994-),硕士研究生,从事妇科肿瘤临床的研究。
基金资助:
海燕基金(编号:JJZD2017-01);国家自然科学基金资助项目(编号:81872507);Nn10计划(编号:Nn10py2017-01)

Research progress in 3D cell culture model of ovarian cancer tumor microenvironment

ZHANG Huiting, LOU Ge

Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2018-12-21 Revised:2019-01-22 Published:2019-12-28

摘要/Abstract

摘要： 卵巢癌(Ovarian cancer,OC)是一种具有侵袭性和致命性的癌症。越来越多的研究表明,肿瘤微环境(Tumor microenvironment,TME)通过各种机制参与促进卵巢癌发生、发展、免疫抑制和炎性反应。TME包括肿瘤血管和淋巴管,以及肿瘤细胞、间质细胞、免疫细胞和细胞外基质(ECM)等。本文结合近年来的文献报道,综述了目前常用的卵巢癌TME三维细胞培养模型,以及总结了许多不包含原始基质细胞的三维模型,旨在总结和寻找卵巢癌治疗的新途径和新方法。

关键词: 卵巢癌, 肿瘤微环境, 三维模型

Abstract: Ovarian cancer(OC)is an aggressive and fatal cancer.A growing number of studies have shown that the tumor microenvironment(TME)is involved in the promotion and development of ovarian cancer,immunosuppression and inflammatory response through various mechanisms.TME includes tumor blood vessels and lymphatic vessels,as well as cancer cells,mesenchymal cells,immune cells,and extracellular matrix(ECM).Based on recent literature reports,this paper reviews the commonly used three-dimensional(3D)cell culture model of ovarian tumor microenvironment,and summarizes many 3D models that do not contain primitive stromal cells,aiming to find new approaches for ovarian cancer treatment.

Key words: Ovarian cancer, Tumor microenvironment, 3D cell culture models

中图分类号:

R737.31

张慧婷, 娄阁. 卵巢癌肿瘤微环境的三维细胞培养模型研究进展[J]. 实用肿瘤学杂志, 2019, 33(6): 557-560.

ZHANG Huiting, LOU Ge. Research progress in 3D cell culture model of ovarian cancer tumor microenvironment[J]. Journal of Practical Oncology, 2019, 33(6): 557-560.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2019.06.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2019/V33/I6/557

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卵巢癌肿瘤微环境的三维细胞培养模型研究进展

Research progress in 3D cell culture model of ovarian cancer tumor microenvironment

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