CXCR4、VEGF在原发性睾丸淋巴瘤中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2020.04.008

摘要/Abstract

摘要： 目的检测CXCR4与VEGF在原发性睾丸淋巴瘤(PTL)中的表达,探讨二者与中枢神经系统浸润和预后的关系。方法运用免疫组化方法,对59例睾丸淋巴瘤肿瘤组织中的CXCR4和VEGF蛋白表达水平进行检测,分析CXCR4和VEGF蛋白的表达情况以及与各项临床病理特征和预后之间的关系。结果 CXCR4和VEGF蛋白表达高的患者更易中枢神经系统浸润(P＜0.05);两者表达水平存在相关性(φ=0.423,P=0.001);CXCR4蛋白的表达与Ann Arbor分期、IPI评分、血清LDH水平、Ki67密切相关,VEGF蛋白的表达与Ann Arbor分期、IPI评分、B症状、血清LDH水平、是否复发、CR状态密切相关;Ann Arbor分期、IPI评分、B症状、血清LDH水平、CNS受累、完全缓解状态、CXCR4和VEGF蛋白表达水平可能是患者PFS和OS的影响因素,CR状态、CXCR4和VEGF蛋白的表达是PTL患者预后的独立影响因素,是预后差的重要因素。结论 CXCR4、VEGF蛋白高表达的患者具有较高的中枢神经系统受累的风险,因此可作为预测指标,针对高表达的患者提前做好预防措施,进而改善预后;并且可作为潜在的治疗靶点,为临床治疗提供更多的选择。

关键词: 原发性睾丸淋巴瘤, 中枢神经系统受累, CXCR4, VEGF

Abstract: Objective The aim of this study was to investigate the expression of CXC chemokine receptor 4(CXCR4)and angiogenic proteins vascular endothelial growth factor(VEGF)in primary testicular lymphoma(PTL),and to analyze the relationship between the expression of CXCR4 and VEGF with CNS invasion and prognosis. Methods Immunohistochemical method was used to detect the expression of CXCR4 and VEGF proteins in 59 PTL tumor tissues and analyze the relationships of CXCR4 and VEGF expression with various clinical pathological features and prognosis. Results Patients with high expression of CXCR4 and VEGF protein were more prone to central nervous system infiltration;The expression of CXCR4 was correlated to the VEGF expression(φ=0.423,P=0.001);The expression of CXCR4 protein were related to Ann Arbor stage,IPI score,serum LDH level,Ki67;The expression of VEGF protein were related to Ann Arbor stage,IPI score,B symptoms,serum LDH level,recurrence,complete remission status;Univariate analysis confirmed that staging,IPI score,B symptoms,serum LDH level,CNS involvement,complete remission status;The expression of CXCR4 and VEGF proteins were significantly related to the patient's PFS and are important factors for poor prognosis. Conclusion Patients with high expression of CXCR4 and VEGF protein have a higher risk of central nervous system invasion.Therefore,they can be used as predictive indicators for patients with high expression to take preventive measures in advance to improve prognosis,and as a potential therapeutic target to provide more options for clinical treatment.

Key words: Primary testicular lymphoma, Central nervous system involvement, CXCR4, VEGF

中图分类号:

R737.21

苏立乾, 孟宏学. CXCR4、VEGF在原发性睾丸淋巴瘤中的表达及临床意义[J]. 实用肿瘤学杂志, 2020, 34(4): 334-340.

SU Liqian, MENG Hongxue. Expression and clinical significance of CXCR4 and VEGF in primary testicular lymphoma[J]. Journal of Practical Oncology, 2020, 34(4): 334-340.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.04.008

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I4/334

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