低级别胶质瘤复发、恶变中VEGF、EGFR表达的变化及意义

doi:10.3969/j.issn.1002-3070.2012.03.005

实用肿瘤学杂志 ›› 2012, Vol. 26 ›› Issue (3): 214-216.doi: 10.3969/j.issn.1002-3070.2012.03.005

低级别胶质瘤复发、恶变中VEGF、EGFR表达的变化及意义

苏君, 张学新, 张锐, 常亮, 金华, 张磊, 王洪滨

哈尔滨医科大学附属第三医院神经外科(哈尔滨 150081)

收稿日期:2011-09-22 出版日期:2012-06-28 发布日期:2014-12-03
通讯作者: 苏君,E-mail:sujun6686@126.com
作者简介:苏君,女,(1966-),博士,主任医师,从事神经肿瘤的个体化化疗
基金资助:
黑龙江省教育厅科学技术研究项目资助(11531187)

The changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma

SU Jun,ZHANG Xuexin,ZHANG Rui,CHANG Liang,JIN Hua,ZHANG Lei,WANG Hongbin

Department of Neurosurgery,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081

Received:2011-09-22 Online:2012-06-28 Published:2014-12-03

摘要/Abstract

摘要： 目的低级别胶质瘤预后的决定因素很多,但即使是相同情况下预后也可以明显不同。部分低级别胶质瘤术后很快复发,且伴有病理级别的升高,这部分病人的预后较差。本研究旨在探讨在低级别胶质瘤复发恶变中VEGF和EGFR表达的变化,并分析这些变化的意义。方法采用免疫组化SP二步法对24对初发低级别及复发、恶变后高级别胶质瘤标本分别进行VEGF和EGFR的表达检测,分析它们在低级别胶质瘤初发和复发、恶变过程中的表达差异。结果与初发的低级别胶质瘤标本相比,VEGF、EGFR在复发、恶变后的表达率明显升高,其表达差异有统计学意义(P＜0.05)。结论本研究表明VEGF和EGFR在低级别胶质瘤复发、恶变中起到非常重要的作用。VEGF和EGFR的表达可以作为低级别胶质瘤预后的指标之一,并为今后胶质瘤的靶向治疗提供理论依据。

Abstract: Objective There are many factors associated with the prognosis of the patients with low grade gliomas(LGG).In some cases,the prognosis of the patients with low grade glioma differ completely,althrough using the same treatment.Some of the patients with LGG soon reccured after operation,following by malignant development.The prognosis of these patients was very poor.This stduy was to detect the changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma.Methods The expressions of VEGF and EGFR in 24 pairs of cases with primary LGG as well as recurrent and malignant development were examined by using immunohistochemical SP method.The different expressions of VEGF and EGFR in the patients with LGG as well as recurrent and malignant development were analyzed.Results The expressions of VEGF and EGFR in the patients with recurrent and malignant development were significantly increased,compared with the patients with primary LGG(P＜0.05).Conclusions The expressions of VEGF and EGFR played an important role in the patients with recurrent and malignant development of low grade gliomas.The expressions of VEGF and EGFR may be used as an indicator of poor prognosis for the patients with low grade glioma.It also provided a theroic basis of target therapy for the patients with glioma.

中图分类号:

R739.41

苏君, 张学新, 张锐, 常亮, 金华, 张磊, 王洪滨. 低级别胶质瘤复发、恶变中VEGF、EGFR表达的变化及意义[J]. 实用肿瘤学杂志, 2012, 26(3): 214-216.

SU Jun,ZHANG Xuexin,ZHANG Rui,CHANG Liang,JIN Hua,ZHANG Lei,WANG Hongbin. The changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma[J]. PRACTICAL ONCOLOGY JOURNAL, 2012, 26(3): 214-216.

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低级别胶质瘤复发、恶变中VEGF、EGFR表达的变化及意义

The changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma

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