Claudin家族蛋白在炎症性肠病及肠炎相关性结直肠癌中的研究进展

doi:10.11904/j.issn.1002-3070.2024.03.010

摘要/Abstract

摘要： 近年来,肠道黏膜屏障的产生、维持及调节成为炎症性肠病(Inflammatory bowel disease,IBD)和肠炎相关性结直肠癌(Colitis-associated colorectal cancer,CAC)发生发展及治疗预后方面的研究重点。紧密连接(Tight junction,TJ)蛋白是肠道黏膜屏障的重要组成部分,其中,Claudin家族蛋白成为相关研究热点。本综述主要介绍Claudin蛋白在IBD和CAC中的变化情况,及在IBD和CAC发生发展和临床治疗中作用的最新研究。

关键词: Claudin蛋白, 炎症性肠病, 肠炎相关性结直肠癌, 肠道屏障, 紧密连接蛋白

Abstract: In recent years,the generation,maintenance and regulation of the intestinal mucosal barrier have become a research focus in the occurrence,development,treatment,and prognosis of inflammatory bowel disease(IBD)and colitis associated colorectal cancer(CAC).Tight junction(TJ)proteins are an important component of the intestinal mucosal barrier,which the Claudin family proteins have become a research hotspot.This review mainly introduces the changes of Claudin protein in IBD and CAC,as well as the latest research progress on its role in the occurrence,development and clinical treatment of IBD and CAC.

Key words: Claudin protein, Inflammatory bowel disease, Colorectal cancer associated with enteritis, Intestinal barrier, Tight junction protein

中图分类号:

R735.35

曾睿智, 李永强. Claudin家族蛋白在炎症性肠病及肠炎相关性结直肠癌中的研究进展[J]. 实用肿瘤学杂志, 2024, 38(3): 207-212.

ZENG Ruizhi, LI Yongqiang. Research progress of Claudin family proteins in inflammatory bowel disease and colitis associated colorectal cancer[J]. Journal of Practical Oncology, 2024, 38(3): 207-212.

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