关键词: 结直肠癌癌前病变, 腺瘤, 炎症性肠病, EQ-5D-5L量表, 效用值

Abstract:

Objective The aim of this study was to measure the health-related quality of life in patients with colorectal cancer precancerous lesions using EQ-5D-5L scale and explore the influencing factors. Methods A questionnaire was conducted on the patients who met the inclusion criteria in four tertiary hospitals in Heilongjiang province.The health utility value calculation was based on China's EQ-5D utility value integration system.Univariate analysis was performed using t-test and analysis of variance,and statistically significant influencing factors were included in multiple linear regression model for multivariate analysis. Results There were 229 adenomas and 109 inflammatory bowel disease(IBD)in 338 patients with precancerous lesions.The average health effects of patients with precancerous lesions,adenomas,and IBD was 0.835,0.891,and 0.720,respectively.The highest proportion of patients with self-reported problems was“anxiety or depression”.Patients with older age,low income levels,more severe anxiety and depression,higher severity of illness,low levels of social support,active disease,and no health insurance had low health utility values. Conclusion Age,income,anxiety and depression,severity of illness,social support level,disease activity and medical insurance are the main influencing factors for health-related quality of life in patients with colorectal cancer precancerous lesions.

Key words: Colorectal cancer precancerous lesion, Adenoma, Inflammatory bowel disease, EQ-5D-5L scale, Utility value