Arg-1在大肠炎症相关性肿瘤中的表达及意义

doi:10.11904/j.issn.1002-3070.2016.04.010

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (4): 339-345.doi: 10.11904/j.issn.1002-3070.2016.04.010

Arg-1在大肠炎症相关性肿瘤中的表达及意义

吴杨佳子,鹿晓麟,赵琦,高玉艳,张艳桥

哈尔滨医科大学附属肿瘤医院生物治疗中心(哈尔滨 150081)

收稿日期:2016-04-20 出版日期:2016-08-10 发布日期:2016-08-19
通讯作者: 张艳桥,E-mail:yanqiaozhang@ems.hrbmu.edu.cn
作者简介:吴杨佳子,女,(1984-),硕士,住院医师,从事肿瘤细胞免疫治疗的研究

The expression and significance of Arg-1 in colon inflammation-related tumors

WU Yangjiazi,LU Xiaolin,ZHAO Qi,GAO Yuyan,ZHANG Yanqiao

The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2016-04-20 Online:2016-08-10 Published:2016-08-19

摘要/Abstract

摘要： 目的观察精氨酸酶-1(Arg-1)在小鼠及人的大肠炎症相关性肿瘤组织中的表达情况,分析其与大肠癌患者临床病理因素、增殖和预后的关系。方法采用免疫组化方法观察Arg-1在20例小鼠大肠炎-癌模型中的表达情况,同时观察Arg-1在20例患者大肠的癌旁组织、15例炎症组织、110例癌症组织中的表达情况。应用统计学分析Arg-1在小鼠及人的大肠组织中不同组间的差异表达情况。结果 Arg-1在小鼠大肠的正常组织、慢性炎症组织、腺瘤组织、炎癌组织中表达逐渐升高,具有统计学意义(P＜0.05);Arg-1在患者大肠的癌旁组织、炎症组织、癌症组织中的表达也逐步增高,具有统计学意义(P＜0.05)。结论 Arg-1蛋白与大肠癌的TNM分期密切相关,其可能参与大肠炎症相关性肿瘤的发生与发展过程,并可能成为评估结直肠癌增殖程度及判断预后的候选标志物。

关键词: 精氨酸酶-1, 腺瘤, 大肠癌

Abstract: Objective To analyze the relationship between Arg-1 expression and the clinical pathological factors,proliferation and prognosis value in patients with colorectal cancer.Methods The expression of Arg-1 was observed in normal tissues,chronic inflammatory tissues,and adenomas inflammatory carcinoma tissues of mice.At the same time,Arg-1 expression was observed in human colorectal cancer adjacent tissues,inflamed tissues and colorectal cancer tissues.Arg-1 expressed in 20 cases colorectal inflammation-cancer model in mice.Arg-1 expressed in 20 normal colorectal tissues.Fiftheen colitis tissues and 110 colorectal cancer tissues were examined by Immunohistochemistry.Statistical analysis was used to analyze the changes of Arg-1 expression in different groups of mice and human colon tissue cases.Results Arg-1 protein expression in normal tissues of mice was gradually increased in colon,chronic inflammatory tissues,adenomas,inflammatory carcinoma,with statistical significances(P<0.05).Arg-1 expression in para-carcinoma tissue,colitis tissues,colorectal cancer tissues was gradually increased with statistical significance(P<0.05).Conclusion Arg-1 protein is associated with colorectal cancer TNM stage.Arg-1 protein may be involved in occurrence and development process of inflammation-associated colon tumor and may be a candidate of proliferated and prognostic biomarker in patients with colorectal cancer.

Key words: Arginase-1, Adenomas, Colorectal cancer

中图分类号:

R735.34

吴杨佳子,鹿晓麟,赵琦,高玉艳,张艳桥. Arg-1在大肠炎症相关性肿瘤中的表达及意义[J]. 实用肿瘤学杂志, 2016, 30(4): 339-345.

WU Yangjiazi,LU Xiaolin,ZHAO Qi,GAO Yuyan,ZHANG Yanqiao. The expression and significance of Arg-1 in colon inflammation-related tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 339-345.

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Arg-1在大肠炎症相关性肿瘤中的表达及意义

The expression and significance of Arg-1 in colon inflammation-related tumors

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