乳酸化修饰:癌症治疗中的新兴靶点

doi:10.11904/j.issn.1002-3070.2025.05.011

实用肿瘤学杂志 ›› 2025, Vol. 39 ›› Issue (5): 433-436.doi: 10.11904/j.issn.1002-3070.2025.05.011

乳酸化修饰:癌症治疗中的新兴靶点

辛鑫¹, 熊文婧¹, 张春暖¹, 李晓静¹, 高雪² 综述, 张悦¹ 审校

1.哈尔滨医科大学附属肿瘤医院肿瘤内科(哈尔滨 150081);
2.中国人民武装警察部队黑龙江省总队医院特色专业一科

收稿日期:2024-12-26 修回日期:2025-04-16 出版日期:2025-10-28 发布日期:2025-11-07
通讯作者: 张悦,E-mail:zhangyue010@hotmail.com
作者简介:辛鑫,女,(2000—),硕士研究生,从事乳腺癌治疗方面的研究。
基金资助:
北京医学奖励基金(编号:YXJL-2020-1225-0323)

Lactylation modification:an emerging target in cancer therapy

XIN Xin¹, XIONG Wenjing¹, ZHANG Chunnuan¹, LI Xiaojing¹, GAO Xue², ZHANG Yue¹

1. Department of Medical Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China;
2. Specialized Department Ⅰ,Chinese People's Armed Police Force Heilongjiang Provincial Corps Hospital

Received:2024-12-26 Revised:2025-04-16 Online:2025-10-28 Published:2025-11-07

摘要/Abstract

摘要： 蛋白质翻译后修饰是调控癌症发展和免疫反应的关键机制,已成为癌症诊治的重要靶点。其中,乳酸化修饰通过影响代谢和表观遗传,为肿瘤的精准防控提供了新视角。乳酸化修饰精确调控组蛋白和非组蛋白功能,影响肿瘤细胞特性、微环境酸化及免疫细胞功能,成为连接代谢重编程与恶性表型的关键枢纽。本文综述了乳酸化修饰在肿瘤发生发展、免疫逃逸及临床转化中的作用,并探讨了靶向抑制乳酸化修饰及其相关通路和抑制关键酶活性的可能性。

关键词: 翻译后修饰, 乳酸化, 癌症, 肿瘤微环境

Abstract: Post-translational modification of protein is a key mechanism for regulating cancer development and immune responses,and has become an important target for cancer diagnosis and treatment.Among them,lactylation modification provides a new perspective for the precise prevention and control of tumors by affecting metabolism and epigenetics.Lactylation modification precisely regulates the functions of histone and non-histone,affecting tumor cell characteristics,microenvironment acidification,and immune cell functions,becoming a key hub connecting metabolic reprogramming and malignant phenotypes.This article reviews the regulatory roles of lactylation modification in tumor development,immune escape,clinical translation,and explores the potential of targeted inhibition of lactylation modification and its related pathways,as well as the inhibition of key enzyme activity.

Key words: post-translational modification, lactylation, cancer, tumor microenvironment

中图分类号:

R730.2

辛鑫, 熊文婧, 张春暖, 李晓静, 高雪, 张悦. 乳酸化修饰:癌症治疗中的新兴靶点[J]. 实用肿瘤学杂志, 2025, 39(5): 433-436.

XIN Xin, XIONG Wenjing, ZHANG Chunnuan, LI Xiaojing, GAO Xue, ZHANG Yue. Lactylation modification:an emerging target in cancer therapy[J]. Journal of Practical Oncology, 2025, 39(5): 433-436.

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乳酸化修饰:癌症治疗中的新兴靶点

Lactylation modification:an emerging target in cancer therapy

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