口腔腺样囊性癌的表观遗传学调控机制研究进展

doi:10.11904/j.issn.1002-3070.2025.05.012

实用肿瘤学杂志 ›› 2025, Vol. 39 ›› Issue (5): 437-444.doi: 10.11904/j.issn.1002-3070.2025.05.012

口腔腺样囊性癌的表观遗传学调控机制研究进展

周晴¹ 综述, 王雅梅² 审校

1.首都医科大学基础医学院2023级口腔医学“5+3”一体化专业(北京 100069);
2.首都医科大学基础医学院生物化学与分子生物学系

收稿日期:2025-04-10 修回日期:2025-06-29 出版日期:2025-10-28 发布日期:2025-11-07
通讯作者: 王雅梅,E-mail:ymwang@ccmu.edu.cn
作者简介:周晴,女,(2005—),本科在读,从事口腔医学方向的研究。
基金资助:
首都医科大学长学制导师项目(编号:CXZDS2024030)

Research progress on epigenetic regulation mechanism of oral adenoid cystic carcinoma

ZHOU Qing¹, WANG Yamei²

1. School of Basic Medical Sciences,Capital Medical University,2023 the“5+3”Integrated Specialty of Oral Medicine Class,Beijing 100069,China;
2. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Capital Medical University

Received:2025-04-10 Revised:2025-06-29 Online:2025-10-28 Published:2025-11-07

摘要/Abstract

摘要： 口腔腺样囊性癌(oral adenoid cystic carcinoma,OACC)是口腔恶性肿瘤之一,具有较强的侵袭和浸润能力,且患者预后较差。研究表明,DNA甲基化、组蛋白修饰、非编码RNA和染色质重塑等表观遗传学机制参与调控OACC的发生、发展、侵袭及转移过程。表观遗传学调控机制的深入研究对OACC的预防、诊断及靶向治疗具有重要的临床意义。本文综述了OACC的表观遗传调控机制和治疗研究的新进展。

关键词: 口腔腺样囊性癌, 表观遗传学, 调控机制

Abstract: Oral adenoid cystic carcinoma(OACC)is one of the malignant tumors from the oral cavity,with strong invasion and infiltration ability,and poor prognosis for patients.Studies have shown that epigenetic mechanisms such as DNA methylation,histone modification,non-coding RNAs,and chromatin remodeling are involved in regulating the occurrence,development,invasion,and metastasis of OACC.The in-depth research of epigenetic regulatory mechanisms has important clinical significance for the prevention,diagnosis,and targeted therapy of OACC.This article reviews the epigenetic regulatory mechanisms and new advances in therapeutic research of OACC.

Key words: oral adenoid cystic carcinoma, epigenetics, regulatory mechanisms

中图分类号:

R739.8

周晴, 王雅梅. 口腔腺样囊性癌的表观遗传学调控机制研究进展[J]. 实用肿瘤学杂志, 2025, 39(5): 437-444.

ZHOU Qing, WANG Yamei. Research progress on epigenetic regulation mechanism of oral adenoid cystic carcinoma[J]. Journal of Practical Oncology, 2025, 39(5): 437-444.

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口腔腺样囊性癌的表观遗传学调控机制研究进展

Research progress on epigenetic regulation mechanism of oral adenoid cystic carcinoma

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