关键词: 口腔腺样囊性癌, Ki-67, PTEN, 免疫组织化学

Abstract:

Objective The aims of this study were to determine the expression of Ki-67 and PTEN in oral adenoid cystic carcinoma(OACC)and its relationship with clinicopathological features,and to explore the relationship between the expression of Ki-67 and PTEN.Methods Forty cases of oral adenoid cystic carcinoma were collected from the pathological laboratory in our hospital.Another 15 cases of normal gland in patients with oral adenoid cystic carcinoma were selected as the control group.The expression of Ki-67 protein and PTEN in adenoid cystic carcinoma was detected by immunohistochemistry.Results The positive rate of Ki-67 protein in oral adenoid cystic carcinoma was 70%(28/40),which was significantly higher than that in the control group(2/15)(P＜0.05).The positive rate of PTEN in oral adenoid cystic carcinoma was 63%(25/40),which was significantly higher than that in the control group 20%(3/15)(P＜0.05).They were associated with histological types,metastasis,lymph node metastasis and neural invasion,and not correlated with age,gender and tumor location.The expression of Ki-67 and PTEN in oral adenoid cystic carcinoma may have a significant correlation.Conclusion The expression of Ki-67 and PTEN in adenoid cystic carcinoma is high,and their occurrence and development in adenoid cystic carcinoma play an important role in the process of evolution and metastasis.Ki-67 and PTEN proteins may be markers of oral adenoid cystic carcinoma.

Key words: Adenoid cystic carcinoma of the oral cavity, Ki-67, PTEN, Immunohistochemistry