前列腺癌术后腹股沟疝的发病机制、影响因素及外科防治策略的研究现状与展望

doi:10.11904/j.issn.1002-3070.2025.05.013

实用肿瘤学杂志 ›› 2025, Vol. 39 ›› Issue (5): 445-449.doi: 10.11904/j.issn.1002-3070.2025.05.013

前列腺癌术后腹股沟疝的发病机制、影响因素及外科防治策略的研究现状与展望

罗淇元, 邵泓超, 周绍华综述, 叶木石审校

广东医科大学附属医院泌尿外科(湛江 524000)

收稿日期:2025-06-09 修回日期:2025-09-08 出版日期:2025-10-28 发布日期:2025-11-07
通讯作者: 叶木石,E-mail:19258585640@163.com
作者简介:罗淇元,男,(2000—),硕士研究生,从事泌尿外科相关的研究。
基金资助:
广东省基础与应用基础研究基金项目(编号:2022A1515010684)

The current research status and prospect of the pathogenesis,influencing factors and surgical prevention and treatment strategies of inguinal hernia after prostate cancer surgery

LUO Qiyuan, SHAO Hongchao, ZHOU Shaohua, YE Mushi

Department of Urology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China

Received:2025-06-09 Revised:2025-09-08 Online:2025-10-28 Published:2025-11-07

摘要/Abstract

摘要： 前列腺癌是男性常见恶性肿瘤之一,随着人口老龄化和诊断技术进步,其发病率持续上升。根治性前列腺切除术是治疗局限性前列腺癌的有效手段,但术后腹股沟疝发生率较高,严重影响患者的康复与生活质量。本文系统综述了前列腺癌术后腹股沟疝的发病机制,主要包括解剖结构改变、腹膜前间隙瘢痕形成、鞘状突未闭及术后腹内压增高等方面。并总结了相关影响因素,如手术方式、患者自身条件及术后恢复情况等。在此基础上探讨了外科防治策略,如术中预防性修补、精细化手术操作及术后针对性治疗。同时提出未来研究方向,聚焦于分子生物学机制的深入探索、新型材料的研发及人工智能技术的应用,旨在降低前列腺癌术后腹股沟疝发生率并提升患者生活质量。

关键词: 前列腺癌, 根治性前列腺切除术, 腹股沟疝

Abstract: Prostate cancer is one of the common malignant tumors in men.With the aging of the population and the progress of diagnostic technology,its incidence continues to rise.Radical prostatectomy is an effective treatment for localized prostate cancer.However,the incidence of inguinal hernia after surgery is high,which seriously affects patients'postoperative recovery and quality of life.This article provides a systematic review for the pathogenesis of inguinal hernia after prostate cancer surgery,including changes in anatomical structure,scar formation in the retroperitoneal space,no closure of sheath process,and increased intra-abdominal pressure after surgery.It also summarizes the relevant influencing factors,such as surgical methods,patients'own conditions,and postoperative recovery status.On this basis,surgical prevention and treatment strategies are explored,such as intraoperative preventive repair,refined surgical procedures,and postoperative targeted treatment.At the same time,future research directions are proposed,focusing on the in-depth exploration of molecular biological mechanisms,research and development of new materials,and application of artificial intelligence technology,aiming to reduce the incidence of inguinal hernia after prostate cancer surgery and improving patients' postoperative quality of life.

Key words: prostate cancer, radical prostatectomy, inguinal hernia

中图分类号:

R737.25

罗淇元, 邵泓超, 周绍华, 叶木石. 前列腺癌术后腹股沟疝的发病机制、影响因素及外科防治策略的研究现状与展望[J]. 实用肿瘤学杂志, 2025, 39(5): 445-449.

LUO Qiyuan, SHAO Hongchao, ZHOU Shaohua, YE Mushi. The current research status and prospect of the pathogenesis,influencing factors and surgical prevention and treatment strategies of inguinal hernia after prostate cancer surgery[J]. Journal of Practical Oncology, 2025, 39(5): 445-449.

参考文献

1 Filho AM,Laversanne M,Ferlay J,et al.The GLOBOCAN 2022 cancer estimates:Data sources,methods,and a snapshot of the cancer burden worldwide[J].Int J Cancer,2025,156(7):1336-1346.
2 Wang F,Ma B,Ma Q,et al.Global,regional,and national burden of inguinal,femoral,and abdominal hernias:a systematic analysis of prevalence,incidence,deaths,and DALYs with projections to 2030[J].Int J Surg,2024,110(4):1951-1967.
3 Lade C,Ford H,Venincasa K,et al.No prostate? No problem:Robotic inguinal hernia repair after prostatectomy[J].J Robot Surg,2023,17(4):1757-1761.
4 Aiolfi A,Bona D,Calì M,et al.Is previous radical prostatectomy a contraindication to minimally invasive inguinal hernia repair? A contemporary meta-analysis[J].Hernia.2024,28(5):1525-1536.
5 Kasakewitch JPG,Da Silveira CAB,Inaba ME,et al.Open and minimally invasive inguinal hernia repair for patients with previous prostatectomy:a systematic review and proportional meta-analysis[J].Hernia,2025,29(1):135.
6 Yang Y,Sun M,Chen WM,et al.Adverse postoperative outcomes in elderly patients with sarcopenia[J].BMC Geriatr,2024,24(1):561.
7 Nilsson H,Stranne J,Hugosson J,et al.Risk of hernia formation after radical prostatectomy:a comparison between open and robot-assisted laparoscopic radical prostatectomy within the prospectively controlled LAPPRO trial[J].Hernia,2022,26(1):157-164.
8 Xiang AP,Shen YF,Shen XF,et al.Correlation between the incidence of inguinal hernia and risk factors after radical prostatic cancer surgery:a case control study[J].BMC Urol.2024,24(1):131.
9 Krishnan N,Kakkar A,Nag TC,et al.A comparative study of smooth muscle cell characteristics and myofibroblasts in processus vaginalis of pediatric inguinal hernia,hydrocele and undescended testis[J].BMC Urol.2024,24(1):115.
10 Abdelmotaal YS,Taher H,Kaddah S,et al.Patent processus vaginalis:role of ultrasound in pediatric population with unilateral inguinal hernia and other predictors[J].Pediatr Surg Int.2023,40(1):9.
11 Fernando H,Garcia C,Hossack T,et al.Incidence,predictive factors and preventive measures for inguinal hernia following robotic and laparoscopic radical prostatectomy:A systematic review[J].J Urol,2019,201(6):1072-1079.
12 Soma T,Fukuda S,Matsuyama Y,et al.Peritoneal closure and the processus vaginalis transection method to prevent inguinal hernia after robot-assisted radical prostatectomy[J].Int J Urol,2023,30(6):532-538.
13 Tanaka K,Miyaki Y,Abe K,et al.The outcome of closure of inguinal hernia with laparoscopic percutaneous extraperitoneal closure in young adults[J].World J Surg.2024,48(2):371-376.
14 Soucasse A,Jourdan A,Edin L,et al.A better understanding of daily life abdominal wall mechanical solicitation:Investigation of intra-abdominal pressure variations by intragastric wireless sensor in humans[J].Med Eng Phys,2022,104:103813.
15 Shrestha S,Upadhyay PK.Prevalence of obesity in inguinal hernia repair patients in a tertiary care center[J].JNMA J Nepal Med Assoc,2021,59(234):156-159.
16 Ozawa Y,Aoki K,Koike S,et al.Inguinal hernia leads to worse immediate urinary continence after robot-assisted radical prostatectomy[J].J Robot Surg.2024,18(1):25.
17 朱猛,柳跃鹏,娄雨清,等.不同术式前列腺癌根治术后腹股沟疝发生情况及其危险因素分析[J].临床泌尿外科杂志,2023,38(6):461-465.
18 Wang Z,Li Q,Tang J,et al.Lateral single incision laparoscopic totally extraperitoneal hernioplasty(L-SILTEP)after laparoscopic radical prostatectomy:A rare case report with literature review[J].Medicine(Baltimore).2023,102(32):e34543.
19 Zelicha H,Bell DS,Chen D,et al.Obesity and abdominal hernia in ambulatory patients,2018-2023[J].Hernia.2024,28(4):1317-1324.
20 Rosca R,Paduraru DN,Bolocan A,et al.A comprehensive review of inguinal hernia occurrence in obese individuals[J].Maedica(Bucur),2023,18(4):692-698.
21 Elshalakany NA,Salah AM.Effect of transversus abdominis plane block with or without buprenorphine after inguinal hernia surgery on postoperative pain[J].Anaesthesiol Intensive Ther.2023,55(4):277-284.
22 Cho MR,Lee S,Song SK.A review of sarcopenia pathophysiology,diagnosis,treatment and future direction[J].J Korean Med Sci,2022,37(18):e146.
23 Bhardwaj P,Huayllani MT,Olson MA,et al.Year-over-year ventral hernia recurrence rates and risk factors[J].JAMA Surg.2024,159(6):651-658.
24 Du R,Xiao JW.Inguinal-hernia repair using Lichtenstein combined with Bassini and Halsted techniques[J].Asian J Surg,2024,47(4):2076-2077.
25 Messias BA,Nicastro RG,Mocchetti ER,et al.Lichtenstein technique for inguinal hernia repair:ten recommendations to optimize surgical outcomes[J].Hernia,2024,28(4):1467-1476.
26 Xu LS,Li Q,Wang Y,et al.Current status and progress of laparoscopic inguinal hernia repair:A review[J].Medicine(Baltimore),2023,102(31):e34554.

[1]	董娟, 孔虹倩, 文洪梅, 石青萍, 邵英. 云南省肿瘤登记地区2020年前列腺癌发病和死亡情况及2012—2020年趋势分析[J]. 实用肿瘤学杂志, 2024, 38(6): 383-387.
[2]	韩焱崧, 任明华. 前列腺癌骨转移机制和骨靶向药物研究进展[J]. 实用肿瘤学杂志, 2023, 37(3): 252-256.
[3]	周孟孟, 徐文超, 俞浩. 1990—2019年江苏省男性前列腺癌疾病负担分析[J]. 实用肿瘤学杂志, 2023, 37(1): 1-5.
[4]	李浩, 滕立臣. 外泌体环状RNA在前列腺癌中的研究现状[J]. 实用肿瘤学杂志, 2023, 37(1): 92-96.
[5]	高科, 任明华. 去势抵抗性前列腺癌的药物治疗现状[J]. 实用肿瘤学杂志, 2021, 35(4): 376-379.
[6]	苗鹏程, 康印东, 李富东, 孟冬冬, 王东星, 常德辉. lncRNA SNHGs在前列腺癌发生发展中的研究进展[J]. 实用肿瘤学杂志, 2020, 34(5): 446-450.
[7]	姜涛, 张旭. 孤儿核受体在前列腺癌中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 377-380.
[8]	毛高才，朱其聪，沈宏峰，涂瑞沙，闫庆国. 膀胱与前列腺交界处多向分化癌3例临床病理分析[J]. 实用肿瘤学杂志, 2016, 30(6): 538-542.
[9]	牛德方，崔岩，综述，陈辉，审校. CyclinD1表达与泌尿系统肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2016, 30(6): 547-550.
[10]	赵锐, 孔祥波, 金宁, 张刚. siRNA干扰cytohesins导致前列腺癌细胞中IGFR信号减低[J]. 实用肿瘤学杂志, 2011, 25(4): 361-364.
[11]	李洁冰, 张艳华, 程文, 张本平. 三维能量多普勒对前列腺癌分化程度研究[J]. 实用肿瘤学杂志, 2010, 24(5): 413-414.
[12]	吴迪综述, 张艳华审校. 经直肠三维超声在前列腺癌诊断中的应用进展[J]. 实用肿瘤学杂志, 2009, 23(5): 496-500.
[13]	乔振奎, 徐万海, 王晓民, 苏宇. 白藜芦醇对人前列腺癌PC-3细胞株VEGF的表达及细胞增殖的影响^△[J]. 实用肿瘤学杂志, 2009, 23(3): 242-24.
[14]	朱芳. Survivin蛋白在前列腺癌组织中表达及临床意义的meta分析[J]. 实用肿瘤学杂志, 2007, 21(05): 453-456.
[15]	何晓燕;骆利康;郑俊. AMACR在前列腺癌诊断与鉴别诊断中的应用[J]. 实用肿瘤学杂志, 2007, 21(04): 342-343.

前列腺癌术后腹股沟疝的发病机制、影响因素及外科防治策略的研究现状与展望

The current research status and prospect of the pathogenesis,influencing factors and surgical prevention and treatment strategies of inguinal hernia after prostate cancer surgery

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价