Abstract: Objective To study the expressions of C-met and COX-2 in thyroid papillary cancer(TPC)and to analyze the relationship between their expressions and clinicopathological features.Methods S-P immunocytochemical technique was used to examine the expressions of C-met and COX-2 in 96 cases of TPC and 46 cases of benign tissues,and their relationship with clinicopathological features were analyzed.Results The positive rates of C-met and COX-2 in 96 cases of TPC were 92.71% and 71.88%,showing obvious differences between TPC and benign tissues(P＜0.001).In TPC there is a statistically significant difference of the expression of C-met in older than 45 years and less than 45 years of age(P＜0.05).Difference of COX-2 expression in TPC was statistically significant in patients with and without lymph node metastasis (P＜0.05).The positive expression of COX-2 was closely related to the expression of C-met(r=0.451,P＜0.05).Conclusion The abnormal expressions of C-met and COX-2 could be important significance in the growth and invasion of TPC,and COX-2 might have some relationship with lymph node metastasis.