Abstract: Tricho-rhinophalangeal syndrome-1 gene(TRPS1),a new GATA family member,is highly prevalent in many tissues.It plays an important role in the regulation of cell proliferation and tissue development.The genetic missing of TRPS1 may lead to Tricho-rhinophalangeal syndrome.In recent years,studies have demonstrated that TRPS1 abnormal expression exists in a variety of tumors,and is associated with carcinogenesis,lymph node metastasis,pathological grading and clinical staging.Therefore,TRPS1 is considered as a potential tumor suppressor gene,its overexpression may be one of mechanisms for carcinogenesis and progression of cancer.This review focuses on the role of TRPS1 gene in carcinogenesis and progression of carcinoma,and further to provide a new biomarker for predicting cancer prognosis and therapy.