肿瘤抑制蛋白p33ING1b在消化系统肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2015.03.014

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 254-258.doi: 10.11904/j.issn.1002-3070.2015.03.014

肿瘤抑制蛋白p33ING1b在消化系统肿瘤中的研究进展

戚, 峰^1,2综述, 邰升²审校

1.大兴安岭地区人民医院普外科(加格达奇 165000);#br# 2.哈尔滨医科大学附属第二医院胆胰外科

收稿日期:2015-03-07 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 邰升 E-mail:taisheng1973@gmail.com
作者简介:戚峰,男,(1983－),硕士,主治医师,从事肝胆胰肿瘤基础与临床的研究
基金资助:
吴阶平医学基金会临床科研专项资助基金(320.6750.1245)

Research progresses of tumor inhibiting protein p33ING1b in the tumors of digestive system

QI Feng^1,2,TAI Sheng²

1.Department of General Surgery,The Greater Xingan Range Area People′ s Hospital,Jiagedaqi 165000,China;#br# 2.Department of Biliary and Pancreatic Surgery,The Second Affiliated Hospital of Harbin Medical University

Received:2015-03-07 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

肿瘤抑制蛋白p33ING1b为生长抑制基因-1(ING1)的主要表达产物,它在细胞增殖和细胞周期调控、细胞衰老、DNA损伤修复、细胞凋亡和核染色质重塑中发挥重要作用。其表达异常与肿瘤的发生发展密切相关。本文就肿瘤抑制蛋白p33ING1b在消化系统肿瘤中的研究进展做一综述。

关键词: p33ING1b, 消化系统, 肿瘤

Abstract:

Tumor inhibiting protein p33ING1b is the key expressive product of inhibitor of growth 1.It plays critical role in cell multiplication,period control,senescence,repair of DNA damage,apoptosis,and chromatin remodeling.The abnormal expression of p33ING1b is closely related to the occurrence and development of tumor.This paper reviews tumor inhibiting protein p33ING1b in the research development of tumors in digestive system.

Key words: p33ING1b, Digestive system, Tumor

中图分类号:

戚峰^1,2综述, 邰升²审校. 肿瘤抑制蛋白p33ING1b在消化系统肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(3): 254-258.

QI Feng,TAI Sheng. Research progresses of tumor inhibiting protein p33ING1b in the tumors of digestive system[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 254-258.

参考文献

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肿瘤抑制蛋白p33ING1b在消化系统肿瘤中的研究进展

Research progresses of tumor inhibiting protein p33ING1b in the tumors of digestive system

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