早期肿瘤退缩与肿瘤预后相关性的研究现状

doi:10.11904/j.issn.1002-3070.2016.01.011

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (1): 53-56.doi: 10.11904/j.issn.1002-3070.2016.01.011

早期肿瘤退缩与肿瘤预后相关性的研究现状

赵春泉, 徐建宇综述, 徐向英审校

哈尔滨医科大学附属肿瘤医院放疗科(哈尔滨 150081)

收稿日期:2015-09-23 出版日期:2016-02-28 发布日期:2016-02-25
通讯作者: 徐向英,E-mail:xuxxyy@sohu.com
作者简介:赵春泉,女,(1989-),硕士研究生,从事肿瘤放疗的研究
基金资助:
1.黑龙江省科技合作项目(WB12C101)2.哈尔滨市科技创新人才研究专项基金(2012RFXXS063)

The present research situation on association between tumor prognosis and early tumor shrinkage

ZHAO Chunquan, XV Jianyv, XV Xiangying

Department of Radiation Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-09-23 Online:2016-02-28 Published:2016-02-25

摘要/Abstract

摘要： 早期肿瘤退缩定义为治疗早期进行评价时肿瘤体积退缩率。近年多项研究证实,早期肿瘤退缩对肿瘤预后具有较好预测作用,可作为预测肿瘤预后的一个重要指标。治疗早期寻找到可以预测肿瘤预后的指标,可使患者治疗方案最优化,更大程度改善肿瘤的预后。本文就早期肿瘤退缩与肿瘤预后的关系进行综述。

关键词: 早期肿瘤退缩, 肿瘤, 治疗, 预后

Abstract: Early tumor shrinkage(ETS)is defined as the reduction rate of tumor volume evaluated in early treatment.In recent years,mutiple studies have demonstrated that ETS predicted tumor prognosis well,it can be used as an important predictor of prognosis.Finding a predictor in the early phase of treatment can optimize treatment regimens and ameliorate the prognosis of tumor.We summarize the research progress of the relationship between ETS and prognosis.

Key words: Early tumor shrinkage, Tumor, Therapy, Prognosis

中图分类号:

R730.5

赵春泉, 徐建宇综述, 徐向英审校. 早期肿瘤退缩与肿瘤预后相关性的研究现状[J]. 实用肿瘤学杂志, 2016, 30(1): 53-56.

ZHAO Chunquan, XV Jianyv, XV Xiangying. The present research situation on association between tumor prognosis and early tumor shrinkage[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 53-56.

参考文献

1 Teo P,Yu P,Lee WY,et al.Significant prognosticators after primary radiotherapy in 903 nondiddeminated nasopharyngeal carcinoma evaluated by computer tomography[J].Int J Radiat Oncol Biol Phys,1996,36(2):291-304.
2 Willner J,Baier K,Pfreundner L,et al.Tumor volume and local control in primary radiotherapy of nasopharyngeal carcinoma[J].Acta Oncol,1999,38(8):1025-1030.
3 Chang CC,Cheu MK,Liu MT,et al.The effect of primary tumor volumes in advanced T-staged nasopharyngeal tumors[J].Head Neck,2002,24(10):940-946.
4 Kim ST,Jang KT,Lee SJ,et al.Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer[J].BMC Cancer,2015,15:530.
5 Modest DP,Laubender RP,Stintzing S,et al.Early tumor shrinkage in patients with metastatic colorectal cancer receiving first-line treatment with cetuximab combined with either CAPIRI or CAPOX:An analysis of the German AIO KRK 0104 trial[J].Acta Oncologica,2013,52(5):956-962.
6 Heinemann V,Stintzing S,Modestet DP,et al.Early tumour shrinkage(ETS)and depth of response(DpR)in the treatment of patients with metastatic colorectal cancer(mCRC)[J].Euro J of Cancer,2015,(14)51:1927-1936.
7 王孝深,胡超苏,吴永如,等.鼻咽癌常规放疗中肿瘤退缩速度对预后的影响[J].中华放射肿瘤学杂志,2005,14(1):6-9.
8 Denekamp J.Tumor regression as a guide to prognosis:a study with experimental animals[J].Br J Radiol,1977,50(592):271-279.
9 Denys D,Kumar P,Wong FS,et al.The predictive value of tumor regression rates during chemoradiation therapy in patients with advanced head and neck squamous cell carcinoma[J].Am J Surg,1997,174(5):561-564.
10 Okada H,Hontsu S,Miura S,et al.Changes of tumor size and tumor contrast enhancement during radiotherapy for non-small-cell lung cancer may be suggestive of treatment response[J].J Radiat Res,2012,53(2):326-332.
11 陈波,高黎,徐国镇,等.鼻咽癌放疗中影像所示肿瘤退缩情况与远期预后的关系[J].肿瘤学杂志,2009,15(5):371-375.
12 Siker ML,Tomé WA,Mehta MP,et al.Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy:how reliable,consistent,and meaningful is the effect?[J].Int J Radiat Oncol Biol Phys,2006,66(1):135-141.
13 Ramsey CR,Langen KM,Kupelian PA,et al.A technique for adaptive image-guided helical tomotherapy for lung cancer[J].Int J Radiat Oncol Biol Phys,2006,64(4):1237-1244.
14 Bosmans G,van Baardwijk A,Dekker A,et al.Intrapatient variability of tumor volume and tumor motion during conventionally fractionated radiotherapy for locally advanced non-small-cell lung cancer:A prospective clinical study[J].Int J Radiat Oncol Biol Phys,2006,66(3):748-753.
15 Fox J,Ford E,Redmond K,et al.Quantification of tumor volume changes during radiotherapy for non-small-cell lung cancer[J].Int J Radiat Oncol Biol Phys,2009,74(2):341-348.
16 Suzuki C,Blomqvist L,Sundin A,et al.The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy[J].Ann Oncol,2012,23(4):948-954.
17 Giessen C,Laubender RP,Fischer von Weikersthal L,et al.Early tumor shrinkage in metastatic colorectal cancer:retrospective analysis from an irinotecan-based randomized first-line trial[J].Cancer Sci,2013,104(6):718-724.
18 Douillard JY,Siena S,Peeters M,et al.Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer[J].Eur J Cancer,2015,51(10):1231-1242.
19 Petrelli F,Pietrantonio F,Cremolini C,et al.Early tumour shrinkage as a prognostic factor and surrogate end-point in colorectal cancer:A systematic review and pooled-analysis[J].Eur J Cancer,2015,51(7):800-807.
20 Piessevaux H,Buyse M,Schlichting M,et al.Use of early tumor shrinkage to predict long-term outcome in metastatic colorectal cancer treated with cetuximab [J].J Clin Oncol,2013,31(30):3764-3775.
21 Krajewski KM,Franchetti Y,Nishino M,et al.10% Tumor diameter shrinkage on the first follow-up computed tomography predicts clinical outcome in patients with advanced renal cell carcinoma treated with angiogenesis inhibitors:a follow-up validation study[J].Oncologist,2014,19(5):507-514.
22 Miyake H,Miyazaki A,Imai S,et al.Early tumor shrinkage under treatment with first-line tyrosine kinase inhibitors as a predictor of overall survival in patients with metastatic renal cell carcinoma:a retrospective multi-institutional study in japan[J].Target Oncol,2015,4[Epub ahead of print].
23 Kim ST,Jang KT,Lee SJ,et al.Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer[J].BMC Cancer,2015,21(15):530.
24 Birchard KR,Hoang JK,Herndon JE,et al.Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival[J].Cancer,2009,115(3):581-586.

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早期肿瘤退缩与肿瘤预后相关性的研究现状

The present research situation on association between tumor prognosis and early tumor shrinkage

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